• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of anesthetics on sepsis-induced cerebral inflammatory cytokine upregulagtion

Research Project

Project/Area Number 25462432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKyoto University

Principal Investigator

Tanaka Tomoharu  京都大学, 医学(系)研究科(研究院), 助教 (10402893)

Co-Investigator(Renkei-kenkyūsha) HIROTA Kiichi  関西医科大学, 医学部, 准教授 (00283606)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマイクログリア / IL-1b / 麻酔薬 / 炎症性サイトカイン / マイクリグリア / IL-1
Outline of Final Research Achievements

General anesthetics including isoflurane and propofol time-and dose-dependently suppressed inflammatory cytokine, especially IL-1b, upregulation induced by LPS in microglia cell line. Both anesthetics significantly suppressed the phosphorylation of MAPK, and the result suggested that the effect of anesthetics on MAPK is the essential mechanism of cytokine suppression. In the experiment adopting sepsis model mice, isoflurane significantly suppressed IL-1b induction in brain, and decreased ACTH concentration in blood. Those results suggested that general anesthetics affect the sepsis-induced IL-1b induction in brain, and may have a great impact on stress response using hypothalamus-adrenal gland axis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] General Anesthetics Inhibit LPS-Induced IL-1beta Expression in Glial Cells.2013

    • Author(s)
      Tanaka T, Kai S, Matsuyama T, Adachi T, Fukuda K, Hirota K.
    • Journal Title

      PLoS ONE.

      Volume: 8 Issue: 12 Pages: 82930-82930

    • DOI

      10.1371/journal.pone.0082930

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 麻酔薬は敗血症時の視床下部における炎症性サイトカイン誘導を抑制する。2013

    • Author(s)
      田中 具治、廣田 喜一、甲斐 慎一、松山 智紀、福田 和彦
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi