| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We analyzed the effects of haloperidol on dendritic cell (DC) and DC-mediated immune response. haloperidol suppressed the maturation of immature DCs induced by LPS. Furthermore, we analyzed the effect of haloperidol on DC-mediated immune response by the use of contact hypersensitivity model of mouse. Haloperidol-treated DC suppressed the development of contact hypersensitivity in mouse. This model is assumed to be developed by typical Th1 immune response. Out results strongly suggest that haloperidol suppress the maturation of immature DCs and the development of Th1 type immune response. In addition, the inhibitory effect was mediated by dopamine D2-like receptor via the inhibition of NF-κB in immune cells such as macrophages and DCs.
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