Gene Therapy for Chronic pain by modulating the SNPs of pacemaker ion channels.

• Project/Area Number: 25462436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Okayama University
• Principal Investigator: Ryuji Kaku 岡山大学, 医歯(薬)学総合研究科, 助教 (50444659)
• Co-Investigator(Kenkyū-buntansha): OBATA Norihiko 神戸大学, 医学部附属病院, 助教 (30509443)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性痛 / 遺伝子治療 / ペースメーカーチャンネル / 神経障害性痛 / 痛みの遺伝子治療

Outline of Final Research Achievements

The pace maker ion channels play a major role on regulating the neuropathic pain, especially it work as modulator at the shift state from acute pain to chronic pain. It is also reported that the SNPs of that ion channels do not pass the current, but it exist on the cell surface. We investigated that cyclic AMP can reduce the expression that ion channels to the cell membrane, and it also can decrease the pain behavior of rat spinal nerve ligation (SNL) model. It suggests that over expression of SNPs ion channels can reduce the pain current, and may inhibit the shift from acute pain to chronic pain.