| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
One of the devastating complications after thoracoabdominal aortic surgery is paraplegia. Paraplegia is thought to be a result of spinal cord ischemia during aortic occlusion. To protect against ischemic spinal cord injury, many drugs have been tested in animal experiments. However, no drugs have been established as being protective in the clinical setting. In this study, we examined neuroprotective effects of the activation of neuroglobin on the neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits. Our results suggest that valproic acid that is thought to activate neuroglobin does not protect against ischemic spinal cord injury in rabbits.
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