Hepatoprotective Effects of Hydrogen Sulfide against Acute Liver Failure
| Project/Area Number |
25462439
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 硫化水素 / 急性肝不全 |
|---|
| Outline of Final Research Achievements |
The aim of this study was to determine whether hydrogen sulfide exerts hepatoprotective effects against acute liver failure, and if so, to elucidate the precise mechanisms by which hydrogen sulfide prevents acute liver failure. The following findings were obtained through this study: 1. Hydrogen sulfide improved survival of acute liver failure mice, which was associated with the attenuation of liver injury. 2. One of the mechanisms by which hydrogen sulfide improved survival of the liver failure mice was at least in part by anti-apoptotic effects of hydrogen sulfide. 3. The anti-apoptotic effects of hydrogen sulfide was via caspase-dependent pathway.
|
Report
(3 results)
Research Products
(3 results)
