Hepatoprotective Effects of Hydrogen Sulfide against Acute Liver Failure

Research Project

Project/Area Number	25462439
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology
Research Institution	Kyushu University
Principal Investigator	Tokuda Kentaro 九州大学, 大学病院, 助教 (10419567)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	硫化水素 / 急性肝不全
Outline of Final Research Achievements	The aim of this study was to determine whether hydrogen sulfide exerts hepatoprotective effects against acute liver failure, and if so, to elucidate the precise mechanisms by which hydrogen sulfide prevents acute liver failure. The following findings were obtained through this study: 1. Hydrogen sulfide improved survival of acute liver failure mice, which was associated with the attenuation of liver injury. 2. One of the mechanisms by which hydrogen sulfide improved survival of the liver failure mice was at least in part by anti-apoptotic effects of hydrogen sulfide. 3. The anti-apoptotic effects of hydrogen sulfide was via caspase-dependent pathway.

Report

(3 results)