| Project/Area Number |
25462440
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Fukuoka University (2015-2016)
Kyushu University (2013) |
|---|
Principal Investigator |
YAMAURA KEN 福岡大学, 医学部, 教授 (70264041)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大庭 由宇吾 九州大学, 大学病院, 助教 (30567368)
塩川 浩輝 九州大学, 大学病院, 助教 (30572490)
辛島 裕士 九州大学, 医学研究院, 准教授 (80380434)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Yoshimura Megumu 熊本保健科学大学, 大学院生命科学研究科, 教授 (10140641)
|
|---|
| Research Collaborator |
Sumie Makoto 九州大学, 大学院医学研究院麻酔・蘇生学分野, 大学院生
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
|
|---|
| Keywords | 疼痛管理学 / 慢性痛 / ケタミン / 電気生理学 / 急性痛 / in vivo パッチクランプ法 / 脊髄スライスパッチクランプ法 / 脊髄膠様質細胞 / NMDA受容体 |
|---|
| Outline of Final Research Achievements |
We made patch-clamp recordings from substantia gelatinosa neurons in the adult rat spinal dorsal horn in vivo or in spinal cord slices. We revealed that intrathecal administration of Ultiva (remifentanil); to SG neurons hyperpolarized membrane potentials and depressed presynaptic glutamate release predominantly through the activation of glycine receptors. We also found that Ketamine increased presynaptic glutamate release. This result raises the possibility that Ketamine has pronociceptive effect in the spinal cord.
|
