Effects of the glucagon-like peptide-1 receptor agonist on the functional recovery of myocardial stunning in pigs.
Project/Area Number |
25462441
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
|
Research Institution | Nagasaki University |
Principal Investigator |
SHIBATA Itsuko 長崎大学, 病院(医学系), 助教 (10404245)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 心筋虚血再灌流障害 / 心筋スタニング / GLP-1アナログ / 糖尿病治療薬 / 心筋虚血再灌流傷害 / 心筋虚血再潅流障害 |
Outline of Final Research Achievements |
We assessed the effect of liraglutude treatment of the stunned myocardium in anesthetized open chest swine. Administration of the Glucagon-like peptide-1 (GLP-1) analog liraglutide daily hypodermic injections 1 week or 1 day before ischemia protects the stunned myocardium in anesthetized open-chest swine. This cardioprotective effect of liraglutude against myocardial stunning was probably not related to systemic or coronary hemodynamic changes. Administration of GLP-1 analog liraglutide before ischemia protects against myocardial stunning.
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Report
(4 results)
Research Products
(14 results)