noninvasive detection of hepatic ischemia by TRS

• Project/Area Number: 25462443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kagoshima University
• Principal Investigator: YASUDA TOMOTSUGU 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (80437954)
• Co-Investigator(Kenkyū-buntansha): KAKIHANA Yasuyuki 鹿児島大学, 医歯学域 医学部・歯学部附属病院 集中治療部, 教授 (20264426) ; MATSUNAGA Akira 鹿児島大学, 医歯学域 医学部・歯学部附属病院 手術部, 准教授 (70284883)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 虚血 / 酸素化 / 近赤外線分光法 / 肝臓 / ショック / 肝虚血

Outline of Final Research Achievements

Hepatic ischemia is sometimes fatal but it is yet to be well established it non-invasively. However Near-infrared spectroscopy (NIRS) is useful for assessing the oxygenation state in the brain. At present it is not clear whether NIRS provides reliable values on the tissue oxygenation of various organs . The aim of this study was to investigate whether changes in hepatic oxygenation can be detected by one of new NIRS methods (TRS). In the exam using another rabbit, TRS probe was placed on the abdominal skin above the liver surface. During balloon inflation, total Hb concentration gradually increased. It indicated liver congestion was well constructed. As total Hb increased, deoxy-Hb gradually increased too. This means TRS detected the change of liver ischemia. We need reference to confirm TRS can detect not the oxygenation of the skin, but that of the liver. TRS can measure the the change of oxygenation in the liver ischemia percutaneously from the skin.

Research Products

• [Journal Article] Non-invasive Monitoring of Hepatic Oxygenation Using Time-Resolved Spectroscopy. (2016)
  • Author(s): Tomotsugu Yasuda, Keiji Yamaguchi, Takahiro Futatsuki, Hiroaki Furubeppu, Mayumi Nakahara, Tomohiro Eguchi, Shotaro Miyamoto, Yutaro Madokoro, Shinsaku Terada, Kentaro Nakamura, Hiroki Harada, Taniguchi Junichiro, Kosuke Yanagimoto, Yasuyuki Kakihana
  • Journal Title: Oxygen Transport to Tissuue XXXVI Volume: 876 Pages: 407-412
  • DOI: 10.1007/978-1-4939-3023-4_51
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Int'l Joint Research