• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of endogenous NOS inhibitor on pulmonary arterial pressure

Research Project

Project/Area Number 25462447
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionYokohama City University

Principal Investigator

Shinbori Nobuhiro  横浜市立大学, 医学研究科, 客員准教授 (60404993)

Co-Investigator(Kenkyū-buntansha) 渡辺 至  横浜市立大学, 医学研究科, 客員教授 (20534142)
水野 祐介  横浜市立大学, 附属病院, 准教授 (80433192)
川上 裕理  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 医長 (90407958)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺高血圧 / 一酸化窒素 / 内皮細胞 / 一酸化窒素合成酵素 / arginase / ADMA / DDAH / 一酸化窒素合成酵素阻害物質 / ADAM / 内因性NOS阻害物質 / DDAH1 / PRMT2
Outline of Final Research Achievements

Impairment of endogenous release of nitric oxide (NO), which causes vascular vasodilation and inhibition of smooth muscle cell proliferation, is well known to play a critical role in developing pulmonary hypertension (PH). We explored the mechanism of impared ehdothelial function and eNOS activity in PH using monocrotaline-induced PH rats.
Increase in PRMT2 and decrease in DDAH1 and DDAH2 in the PH model were associated with increased ADMA contents and consequent impairment of NOS activity. These results may be potentially useful to lower ADMA level for therapeutic benefit.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report

Research Products

(1 results)

All 2013

All Presentation (1 results)

  • [Presentation] Involvement of increased protein arginine methyltransferases 2 and decreased dimethylarginine dimethylaminohydrolases in impaired NOS activity in pulmonary hypertension in rats2013

    • Author(s)
      Yusuke Mizuno、Hironobu Shinbori, Takahisa Goto
    • Organizer
      Euroanesthesia
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi