Application of biliverdin/bilirubin redox cycle to the novel therapeutic strategy against acute lung injury
| Project/Area Number |
25462450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
Toru Takahashi 岡山県立大学, 保健福祉学部, 教授 (40252952)
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| Co-Investigator(Kenkyū-buntansha) |
MORIMATSU Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (30379797)
OGINO Tetsuya 岡山県立大学, 保健福祉学部, 教授 (90252949)
SHIMIZU Hiroko 岡山大学, 医学部, 客員研究員 (80423284)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性肺傷害 / 出血性ショック / ビリベルジン / 炎症 / 酸化ストレス / 酸化的DNA損傷 / 抗炎症作用 / 抗酸化ストレス作用 / 出血性ショック蘇生 / Heme Oxygenase-1 / 一酸化炭素:CO / COヘモグロビン / CO releasing molecule / 周術期管理学 / 8-OHdG / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
Hemorrhagic shock and resuscitation (HSR) induces pulmonary inflammation that leads to acute lung injury. Biliverdin, a metabolite of heme catabolism, has been shown to have potent anti-inflammatory, and anti-oxidant effects. We administered biliverdin to a rat model of HSR and examined its effect on HSR-induced lung injury. We found that pre-treatment of HSR rats with biliverdin at a dose of 35 mg/kg markedly ameliorated HSR-induced pulmonary inflammation and oxidative tissue injury in the lung as judged by the histopathological improvement, and the decrease in inflammatory gene expression and DNA oxidative damage without abnormal increase in serum bilirubin levels. We also confirmed that biliverdin administration after HSR had protective effects on lung injury. Our findings suggest that biliverdin has a protective role, at least in part, against HSR-induced lung injury through anti-inflammatory and anti-oxidant mechanisms.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples2015
Author(s)
Junichi Taira, Yukinori Nakashima, Shun Yoshihara, Shinya Koga, Shinji Sueda, Hideyuki Komatsu, Yuichiro Higashimoto, Toru Takahashi, Nohito Tanioka, Hiroko Shimizu, Hiroshi Morimatsu, Hiroshi Sakamoto
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Journal Title
Analytical Biochemistry
Volume: 489
Pages: 50-52
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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