| Project/Area Number |
25462462
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
SATA Takeyoshi 産業医科大学, 大学病院, 病院長 (60128030)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HORISHITA Takafumi 産業医科大学, 医学部, 准教授 (40369070)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKURA Dan 産業医科大学, 医学部, 助教 (00596710)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 神経障害性疼痛 / 電位依存性ナトリウムチャネル / Nav1.3サブユニット / Nav1.3選択的阻害薬 / 新たな鎮痛薬開発 |
|---|
| Outline of Final Research Achievements |
We investigated the effects of antidepressants as conventional medications for neuropathic pain, and allopregnanolone sulfate, the metabolite of allopregnanolone that is desired as a new medication for neuropathic pain on voltage-gated sodium channel α subunit, Nav1.3 electrophysiologically in order to contribute the development of selective Nav1.3 inhibitor as a new analgesic for neuropathic pain. We found that these compounds inhibit the function of Nav1.3 dose-dependently. Moreover, we demonstrated that these inhibitory effects were enhanced by co-expression with β3 subunit. These results would help to clarify the mechanisms underlying inhibition of Nav1.3 function, and contribute the development of selective Nav1.3 inhibitor.
|
