Circadian variation of serum hormone concentration in relation with serum melatonin level and tissue clock gene expression in patients receiving prostate needle biopsy

Research Project

Project/Area Number	25462468
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Urology
Research Institution	Gunma University
Principal Investigator	Shibata Yasuhiro 群馬大学, 医学部附属病院, 講師 (90344936)
Co-Investigator(Kenkyū-buntansha)	新井誠二群馬大学, 医学部附属病院, 助教 (10636210)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords	ホルモン / 日内変動 / 前立腺 / 時計遺伝子
Outline of Final Research Achievements	Serum hormone concentrations in adult males vary in a circadian manner. This study aimed to clarify the relationship between circadian variation of serum hormones and prostate disease in patients under well-controlled conditions who are hospitalized for undergoing a prostate needle biopsy. This study included 109 patients undergoing prostate biopsy. Blood samples were collected for hormone determination twice in morning and afternoon. Serum DHEA-S concentration in the morning was lower in prostate cancer than non-cancer patients. The variation of melatonin was smaller in prostate cancer than non-cancer patients. Clock genes PER2 and CLK were well expressed in the needle biopsy specimen, but there were no significant relation with prostate diseases.