Circadian variation of serum hormone concentration in relation with serum melatonin level and tissue clock gene expression in patients receiving prostate needle biopsy

• Project/Area Number: 25462468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Gunma University
• Principal Investigator: Shibata Yasuhiro 群馬大学, 医学部附属病院, 講師 (90344936)
• Co-Investigator(Kenkyū-buntansha): 新井 誠二 群馬大学, 医学部附属病院, 助教 (10636210)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: ホルモン / 日内変動 / 前立腺 / 時計遺伝子

Outline of Final Research Achievements

Serum hormone concentrations in adult males vary in a circadian manner. This study aimed to clarify the relationship between circadian variation of serum hormones and prostate disease in patients under well-controlled conditions who are hospitalized for undergoing a prostate needle biopsy. This study included 109 patients undergoing prostate biopsy. Blood samples were collected for hormone determination twice in morning and afternoon.
Serum DHEA-S concentration in the morning was lower in prostate cancer than non-cancer patients. The variation of melatonin was smaller in prostate cancer than non-cancer patients. Clock genes PER2 and CLK were well expressed in the needle biopsy specimen, but there were no significant relation with prostate diseases.

Research Products

• [Presentation] 前立腺生検を要する患者のホルモン日内変動と諸因子の関係
  • Author(s): 柴田康博
  • Organizer: 第102回 日本泌尿器科学会総会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）