| Project/Area Number |
25462480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAGAO Kazuhiro 山口大学, 医学部附属病院, 講師 (70379949)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hiroaki 山口大学, 医学部附属病院, 助教 (60610673)
MATSUYAMA Hideyasu 山口大学, 大学院医学系研究科, 教授 (70209667)
IKEDA Eiji 山口大学, 大学院医学系研究科, 教授 (30232177)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | FABP / renal cell carcinoma / therapeutic target / marker / 脂肪酸結合タンパク / 淡明腎細胞癌 / 治療標的 / 予後予測因子 |
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| Outline of Final Research Achievements |
To identify potential targets in clear cell renal cell carcinoma (ccRCC), we performed an experiment to confirm the significance of FABP7 as a potential target and marker in ccRCC. Our immunohistochemical analysis showed that higher FABP7 expression was significantly correlated with distant metastasis and poor cancer-specific survival in ccRCC. Functional suppression of FABP7 resulted in significant growth inhibition and significant reduction of the invasive potential of a ccRCC cell line. Functional suppression of FABP6 resulted in significant growth inhibition and significant reduction of the invasive potential of another ccRCC cell line.
FABP7 and 6 could be a potential therapeutic target and diagnostic marker in metastatic ccRCC.
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