| Project/Area Number |
25462486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Saga University |
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Principal Investigator |
yuji tokuda 佐賀大学, 医学部, 客員研究員 (90315200)
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| Co-Investigator(Kenkyū-buntansha) |
TODA SHUJI 佐賀大学, 医学部, 教授 (80188755)
NANRI MAKI 佐賀大学, 医学部, 助教 (00448474)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膀胱癌 / 癌幹細胞 / 間質細胞 / 癌ー間質相互作用 / 表在性膀胱癌 / 浸潤性膀胱癌 / 脂肪組織由来間質繊維芽細胞 / 脂肪組織由来間質線維芽細胞 / 癌間質相互作用 |
|---|
| Outline of Final Research Achievements |
Superficial bladder cancer might promote myofibroblast differentiation of adipose tissue stromal cells as a cancer-associate phenotype, whereas invasive bladder cancer might promote their adipocyte differentiation.We examined the expression profile of proteins in these types cultured alone or with ATSCs. The expression of CD147, galectin-3 and galectin-3BP increased in co-culture of superficial type and ATSCs, while that of CD147, galectin-3 and galectin-3BP decreased in co-culture of invasive type and ATSCs. The expression of cathepsin D and CRELD2 decreased in in co-culture of superficial type and ATSCs, while that of cathepsin D and CRELD2 increased in co-culture of invasive type and ATSCs. Opposite expression of CD147, galectin-3, galectin-3BP, cathepsin D and CRELD2 was observed in ATSC-affected superficial and invasive type. Thus, these molecules may be involved in the mechanisms of ATSC-affected differences between superficial and invasive type.
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