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Investigation on clinicopathological signficance and tumor suppressive effects of 4N1K-peptide in bladder cancer

Research Project

Project/Area Number 25462487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagasaki University

Principal Investigator

MIYATA Yasuyoshi  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380888)

Co-Investigator(Kenkyū-buntansha) SAKAI Hideki  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40235122)
望月 保志  長崎大学, 病院(医学系), 講師 (40404256)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords4N1K-peptide / Thrombospondins / Angiogenesis / TWIST / Hemeoxygenase-1 / Human antigen R / Thrombospondin / 膀胱癌 / 血管新生 / 化学発癌マウスモデル
Outline of Final Research Achievements

4N1K-peptide is well-known as a fragment of thrombospondin (TSP)-1 and -2. We reviewed biological significance and pathological role of such TSP family. Furthermore, we found that microvessel density (MVD) measured by anti-CD105 (CD105-MVD) was more useful compared to CD31-MVD or CD34-MVD in urothelial cancer of upper urinary tract. In addition, similar finding was detected in human prostate cancer. Next, we investigated relationship between malignant potential and cancer stromal tissues in human urological cancer tissues because stromal expression of 4N1K-peptide often play important roles in several malignancies. In this grant, we showed pathological significance and prognostic roles of TWIST, hemeoxygenase (HO)-1, and human antigen R (HuR) in urological cancers. In the present, we have been investigated that pathological significance of 4N1K-peptide, TSP-1, and TSP-2 in patients with bladder cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Predictive Markers for the Recurrence of Nonmuscle Invasive Bladder Cancer Treated with Intravesical Therapy.2015

    • Author(s)
      Miyata Y, Sakai H
    • Journal Title

      Disease Markers

      Volume: 2015 Pages: 857416-857416

    • DOI

      10.1155/2015/857416

    • NAID

      120006986816

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement.2015

    • Author(s)
      Miyata Y, Sakai H
    • Journal Title

      International Journal of urology

      Volume: 22 Issue: 9 Pages: 806-815

    • DOI

      10.1111/iju.12840

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer.2015

    • Author(s)
      Miyata Y, Mitsunari K, Akihiro A, Watanabe SI, Mochizuki Y, Sakai H.
    • Journal Title

      Molucular and Clinical Oncology

      Volume: 3 Pages: 287-294

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD105 is a more appropriate marker for evaluating angiogenesis in urothelial cancer of the upper urinary tract than CD31 or CD34.2013

    • Author(s)
      Miyata Y, Sagara Y, Watanabe S, Asai A, Matsuo T, Ohba K, Hayashi T, Sakai H
    • Journal Title

      Virchows Archiv

      Volume: 463 Issue: 5 Pages: 673-679

    • DOI

      10.1007/s00428-013-1463-8

    • NAID

      120006985996

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] High expression of HuR in cytoplasm, but not nuclei, is associated with2013

    • Author(s)
      Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K, Sakai H.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e59095-e59095

    • DOI

      10.1371/journal.pone.0059095

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.2013

    • Author(s)
      Miyata Y, Sakai H.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 14 Issue: 6 Pages: 12249-12272

    • DOI

      10.3390/ijms140612249

    • NAID

      120006986208

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feline sarcoma-related protein expression correlates with maligant aggressiveness and poor prognosis in renal cell carcinoma.2013

    • Author(s)
      Miyata Yasuyoshi
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 681-686

    • DOI

      10.1111/cas.12140

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis.2013

    • Author(s)
      Miyata Yasuyoshi
    • Journal Title

      Urology

      Volume: 81 Issue: 1 Pages: 136-142

    • DOI

      10.1016/j.urology.2012.08.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Pathological roles of HuR expression in prostate cancer2015

    • Author(s)
      Kensuke Mitsunari
    • Organizer
      Americal Urological Assocaition 2015 annual meeting
    • Place of Presentation
      ニューオーリンズ(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationships between c-Fes expression and malignant aggressiveness in bladder cancer in vivo and in vitro2015

    • Author(s)
      Akihiro Asai
    • Organizer
      Americal Urological Assocaition 2015 annual meeting
    • Place of Presentation
      ニューオーリンズ(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上部尿路癌患者における癌関連因子に喫煙が与える影響の検討2015

    • Author(s)
      浅井昭宏
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 尿路癌患者における化学療法の効果予測因子としてのHuman antigen R(HuR)発現の有用性に関する検討2015

    • Author(s)
      宮田康好
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎癌間質組織におけるFerの病理学的役割2014

    • Author(s)
      光成健輔、宮田康好、浅井昭宏、松尾朋博、大庭康司郎、酒井英樹
    • Organizer
      第23回 泌尿器科分子・細胞研究会
    • Place of Presentation
      山形市、ホテルメトロポリタン山形
    • Related Report
      2013 Research-status Report
  • [Presentation] Pathological significance of expressions of thrombospondin (TSP)-1 and 4N1K-peptide in patients with bladder cancer.2013

    • Author(s)
      Miyata Y, Ohba K, Matuso T, Asai A, Mitsunari K, Sakai H
    • Organizer
      The 33rd Congress of the Société Internationale d'Urologie
    • Place of Presentation
      バンクーバー(カナダ)
    • Related Report
      2013 Research-status Report
  • [Presentation] 4N1K-peptideの膀胱癌における病理学的意義2013

    • Author(s)
      宮田康好、酒井英樹
    • Organizer
      第72回 日本癌学会学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Change of HuR expression by intake of green tea polyphenol in chemical induced bladder cancer animal model.2013

    • Author(s)
      Miyata Y, Asai A, Mitsunari K, Matsuo T, Ohba K, Sakai H
    • Organizer
      American Urological Assocaition 2013 annual meeting
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Cigarette smoking induces lymphangiogenesis, but not angiogenesis, and vascular endothelial growth factor-D, but not VEGF-A or VEGF-C in human bladder cancer tissues.2013

    • Author(s)
      Mitsunari K, Miyata Y, Asai A, Matsuo T, Ohba K, Sakai H
    • Organizer
      American Urological Assocaition 2013 annual meeting
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Book] Advanced in the scientific evaluation of bladder cancer and molecular basis for diagnosis and2013

    • Author(s)
      Miyata Y, Sakai H
    • Total Pages
      23
    • Publisher
      InTech
    • Related Report
      2013 Research-status Report
  • [Remarks] 長崎大学病院 泌尿器科・腎移植外科

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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