| Project/Area Number |
25462487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIYATA Yasuyoshi 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380888)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Hideki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40235122)
望月 保志 長崎大学, 病院(医学系), 講師 (40404256)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 4N1K-peptide / Thrombospondins / Angiogenesis / TWIST / Hemeoxygenase-1 / Human antigen R / Thrombospondin / 膀胱癌 / 血管新生 / 化学発癌マウスモデル |
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| Outline of Final Research Achievements |
4N1K-peptide is well-known as a fragment of thrombospondin (TSP)-1 and -2. We reviewed biological significance and pathological role of such TSP family. Furthermore, we found that microvessel density (MVD) measured by anti-CD105 (CD105-MVD) was more useful compared to CD31-MVD or CD34-MVD in urothelial cancer of upper urinary tract. In addition, similar finding was detected in human prostate cancer. Next, we investigated relationship between malignant potential and cancer stromal tissues in human urological cancer tissues because stromal expression of 4N1K-peptide often play important roles in several malignancies. In this grant, we showed pathological significance and prognostic roles of TWIST, hemeoxygenase (HO)-1, and human antigen R (HuR) in urological cancers. In the present, we have been investigated that pathological significance of 4N1K-peptide, TSP-1, and TSP-2 in patients with bladder cancer.
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