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Chemoprevention of prostate cancer using inhibition of PGE2 receptors and HuR suppression by green tea polyphenol

Research Project

Project/Area Number 25462488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagasaki University

Principal Investigator

SAKAI Hideki  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40235122)

Co-Investigator(Kenkyū-buntansha) MIYATA Yasuyoshi  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380888)
OHBA Kojiro  長崎大学, 病院(医学系), 講師 (20593825)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords前立腺癌 / E prostanoid receptor / human antigen R / cyclooxygenase-2 / prostaglandin E2
Outline of Final Research Achievements

Limited information is available on the pathological significance of human antigen R (HuR) in prostate cancer. We studied the relationship between HuR expression and malignant aggressiveness, and expression of cancer-related molecules in prostate cancer. Our results demonstrated that HuR plays important roles in determining malignant aggressiveness and outcome in prostate cancer, via the regulation of cell proliferation, migration, and expression of VEGF-A, -C, and COX-2. The suppression of HuR might be useful for prevention of prostate cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and VEGFs and COX-2 in prostate cancer2016

    • Author(s)
      Mitsunari K, Miyata Y, Asai A, Matsuo T, Shida Y, Hakariya T, Sakai H
    • Journal Title

      Translational Research

      Volume: 印刷中 Pages: 116-128

    • DOI

      10.1016/j.trsl.2016.04.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and VEGFs and COX-2 in prostate cancer2016

    • Author(s)
      Kensuke Mitsunari, Yasuyoshi Miyata, Akihiro Asai, Tomohiro Matsuo, Kojiro Ohba, Yohei Shida, Tomoaki Hakariya, Hideki Sakai
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(仙台市・宮城県)
    • Year and Date
      2016-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 前立腺癌におけるhuman antigen-R の臨床病理学的役割2015

    • Author(s)
      宮田康好, 光成健輔, 浅井昭宏, 酒井英樹
    • Organizer
      第31回前立腺シンポジウム
    • Place of Presentation
      東京コンファレンスセンター・品川(東京都・港区)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Pathological roles of Human antigen R (HuR) expression in prostate cancer2015

    • Author(s)
      Kensuke Mitsunari, Yasuyoshi Miyata, Akihiro Asai, Tomohiro Matsuo, Kojiro Ohba, Kosuke Takehara, Hideki Sakai
    • Organizer
      American Urological Association Annual Meeting 2015
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 前立腺癌におけるHuRの病理学的役割2015

    • Author(s)
      光成 健輔, 浅井 昭宏, 志田 洋平, 松尾 朋博, 大庭 康司郎, 宮田 康好, 酒井 英樹
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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