| Project/Area Number |
25462490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENOKIDA HIDEKI 鹿児島大学, 医歯学域医学系, 准教授 (80347103)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
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| Research Collaborator |
千代丸 剛 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教
井口 智生 鹿児島大学, 医歯学総合研究科, 大学院生
石原 知明 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | マイクロRNA / 膀胱癌 / microRNA / 膀胱がん |
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| Outline of Final Research Achievements |
The expression levels of microRNA-143/145, microRNA-23b/27b, microRNA-451a/144-3p/144-5p, and microRNA-145-5p/3p were down-regulated in bladder cancer tissues compared to normal bladder tissues. These microRNAs target BIRC5, WNT7A, CCNE1, CCNE2, CDC25A, PKMYT1, CCNE1, CCNE2, and UHRF1. The passenger strand had been considered as having no function. However, we newly found that the passenger strand of specific microRNA actually function as strong tumor suppressors. From our experiments, we found new strategy for treatment of bladder cancer.
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