The glycoprotein carrying sialyl T as a possible marker for renal cell carcinoma
Project/Area Number |
25462491
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | University of the Ryukyus |
Principal Investigator |
SAITO Seiichi 琉球大学, 医学(系)研究科(研究院), 教授 (80235043)
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Co-Investigator(Kenkyū-buntansha) |
GOYA Masato 琉球大学, 医学部附属病院, 講師 (50295317)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 腎細胞癌 / 血清マーカー / 糖鎖 / 腫瘍マーカー / 腎癌 |
Outline of Final Research Achievements |
GP-RCC, which has been identified in the process of searching the glycoprotein carrying sialyl T antigen, decreased in the patients with clear cell renal cell carcinoma (RCC). Serum level of GP-RCC was significantly lower in 63 patients with clear cell RCC than in 53 having benign urologic diseases without RCC (p=0.0004). Increase of serum GP-RCC level was confirmed after radical nephrectomy for clear cell RCC in five out of six patients. Molecular size (45kDa) of serum GP-RCC was larger than that (38kDa) extracted from RCC cell lines. Molecular size was decreased by glycosidase treatment of serum GP-RCC, suggesting serum GP-RCC is heavily glycolsylated compared to GP-RCC existing in RCC cell lines. From the results, it was indicated that a decrease of GP-RCC was a new marker for clear cell RCC.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] 80歳以上の高齢者における泌尿器科手術の周術期合併症.2015
Author(s)
宮里実, 與那嶺智子,泉惠一朗,宮城亮太,芦刈明日香,仲西昌太郎,木村隆,松村英理,大城琢磨,呉屋真人,斎藤誠一
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Journal Title
西日本泌尿器科
Volume: 77
Pages: 200-203
Related Report
Peer Reviewed