• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of Angiotensin 1-7 to modulate androgen receptor expression in prostate cancer cells

Research Project

Project/Area Number 25462493
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

Uemura Hiroji  横浜市立大学, 附属市民総合医療センター, 教授 (50244439)

Co-Investigator(Kenkyū-buntansha) Kubota Yoshinobu  横浜市立大学, 学長 (10106312)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords前立腺癌 / レニンーアンジオテンシン系 / アンジオテンシン1-7 / AT2レセプター / レニン-アンジオテンシン系 / レニン‐アンジオテンシン系
Outline of Final Research Achievements

We have reported that renin-angiotensin system is involved in the development and progression of prostate cancer. Angiotensin II (AngII) receptor blocker was proven to have the potential of antitumor effect that was demonstrated by experimental and clinical investigation. This study showed that Angiotensin 1-7 (Ang1-7) which is converted from AngII by angiotensin converting enzyme 2 may have also antitumor effect for prostate cancer. We performed the experiment that demonstrated Ang1-7 may influence androgen receptor in prostate cancer cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2013 2012 Other

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Expression of androgen receptor in non-muscle-invasive bladder cancer predicts the preventive effect of androgen deprivation therapy on tumor recurrence.2016

    • Author(s)
      Izumi K, Ito Y, Miyamoto H, Miyoshi Y, Ota J, Moriyama M, Murai T, Hayashi H, Inayama Y, Ohashi K, Yao M, Uemura H.
    • Journal Title

      Oncotarget

      Volume: 1 Issue: 12 Pages: 1-8

    • DOI

      10.18632/oncotarget.7358

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases.2016

    • Author(s)
      Miyoshi Y, Yoneyama S, Kawahara T, Hattori Y, Teranishi J, Kondo K, Moriyama M, Takebayashi S, Yokomizo Y, Yao M, Uemura H, Noguchi K.
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 128-128

    • DOI

      10.1186/s12885-016-2176-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer.2016

    • Author(s)
      Uemura K, Miyoshi Y, Kawahara T, Yoneyama S, Hattori Y, Teranishi J, Kondo K, Moriyama M, Takebayashi S, Yokomizo Y, Yao M, Uemura H, Noguchi K.
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 109-109

    • DOI

      10.1186/s12885-016-2160-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphoproteome analysis demonstrates the potential role of THRAP3 phosphorylation in androgen-independent prostate cancer cell growth.2016

    • Author(s)
      Ino Y, Arakawa N, Ishiguro H, Uemura H, Kubota Y, Hirano H, Toda T.
    • Journal Title

      Proteomics

      Volume: 7 Pages: 1069-1078

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 前立腺癌におけるレニン・アンジオテンシン系の役割とARBの臨床的意義2016

    • Author(s)
      上村博司
    • Journal Title

      Prostate Journal

      Volume: 3 Pages: 33-40

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy.2015

    • Author(s)
      Kawahara T, Fukui S, Sakamaki K, Ito Y, Ito H, Kobayashi N, Izumi K, Yokomizo Y, Miyoshi Y, Makiyama K, Nakaigawa N, Yamanaka T, Yao M, Miyamoto H, Uemura H
    • Journal Title

      Oncotarget

      Volume: 6(31) Issue: 31 Pages: 32169-32176

    • DOI

      10.18632/oncotarget.5081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death.2013

    • Author(s)
      Sato A, Itcho N, Ishiguro H, Okamoto D, Kobayashi N, Kawai K, Kasai H, Kurioka D, Uemura H, Kubota Y, Watanabe M.
    • Journal Title

      Int J Nanomedicine.

      Volume: 8 Pages: 3151-3160

    • DOI

      10.2147/ijn.s40766

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor blockers and risk of prostate cancer among United States veterans.2013

    • Author(s)
      Rao GA, Mann JR, Bottai M, Uemura H, Burch JB, Bennett CL, Haddock KS, Hébert JR.
    • Journal Title

      J Clin Pharmacol

      Volume: 53 Issue: 7 Pages: 773-778

    • DOI

      10.1002/jcph.98

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible anti-tumor activity of initial treatment with zoledronic acid with hormonal therapy for bone-metastatic prostate cancer in multicenter clinical trial.2013

    • Author(s)
      Uemura H, Yanagisawa M, Ikeda I, Fujinami K, Iwasaki A, Noguchi S, Noguchi K, Kubota Y; Yokohama Bone Metastasis Study Group.
    • Journal Title

      Int J Clin Oncol.

      Volume: 18 Issue: 3 Pages: 472-477

    • DOI

      10.1007/s10147-012-0406-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アンジオテンシンレセプターIIブロッカーの前立腺癌発生予防の実験的検証2013

    • Author(s)
      上村博司、伊藤悠亮、星野耕二、高橋智、窪田吉信
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌

      Volume: 21 Pages: 103-105

    • Related Report
      2013 Research-status Report
  • [Journal Article] Usefulness of Perflubutane Microbubble-Enhanced Ultrasound in Imaging and Detection of Prostate Cancer: Phase 2 Multicenter Clinical Trial2012

    • Author(s)
      Hiroji Uemura
    • Journal Title

      World Journal of Urology

      Volume: 31 Issue: 5 Pages: 1123-1128

    • DOI

      10.1007/s00345-012-0833-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Initial neutrophil-to-lymphocyte ratio (LNR) is a prognostic marker in penile cancer patients2016

    • Author(s)
      T Kawahara, J Kasuga, H Uemura, et al.
    • Organizer
      AUA 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploring novel biomarkers of specific castration resistant prostate cancer (CRPC) by the proteome analysis2016

    • Author(s)
      H Uemura, et al.
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Phase II clinical study of radium-223 chloride (BAY 88-8223) in Japanese patients with symptomatic castration-resistant prostate cancer (CRPC) with bone metastatsis.2016

    • Author(s)
      H Uemura, et al.
    • Organizer
      ASCO-GU 2016
    • Place of Presentation
      San Francisco
    • Year and Date
      2016-01-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancement of anti-tumor activity by initial concurrent treatment with zoledronic acid and hormonal therapy for bone-metastatic prostate cancer in multicenter clinical trial.

    • Author(s)
      H Uemura, M Yanagisawa, I.Ikeda, K Fujinami, S.Noguchi, K Noguchi, Y Kubota, Yokohama Bone Metastasis Study Group,
    • Organizer
      米国泌尿器科学会総会
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2013 Research-status Report
  • [Presentation] Usefulness of contrast enhanced ultrasound in imaging and detection of prostate cancer

    • Author(s)
      Uemura H
    • Organizer
      The 5th Asian conference on ultrasound contrast imaging,
    • Place of Presentation
      台北、中華民国
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 前立腺癌骨転移に対する新たな治療戦略

    • Author(s)
      上村博司
    • Organizer
      第78回日本泌尿器科学会東部総会
    • Place of Presentation
      新潟コンベンションセンター(新潟県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Development of hormonal therapy, efficacy of GnRH antagonist.

    • Author(s)
      Uemura H
    • Organizer
      韓国泌尿器科学会総会
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi