Analysis of Angiotensin 1-7 to modulate androgen receptor expression in prostate cancer cells

• Project/Area Number: 25462493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: Uemura Hiroji 横浜市立大学, 附属市民総合医療センター, 教授 (50244439)
• Co-Investigator(Kenkyū-buntansha): Kubota Yoshinobu 横浜市立大学, 学長 (10106312)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌 / レニンーアンジオテンシン系 / アンジオテンシン1-7 / AT2レセプター / レニン-アンジオテンシン系 / レニン‐アンジオテンシン系

Outline of Final Research Achievements

We have reported that renin-angiotensin system is involved in the development and progression of prostate cancer. Angiotensin II (AngII) receptor blocker was proven to have the potential of antitumor effect that was demonstrated by experimental and clinical investigation. This study showed that Angiotensin 1-7 (Ang1-7) which is converted from AngII by angiotensin converting enzyme 2 may have also antitumor effect for prostate cancer. We performed the experiment that demonstrated Ang1-7 may influence androgen receptor in prostate cancer cells.

Research Products

• [Journal Article] Expression of androgen receptor in non-muscle-invasive bladder cancer predicts the preventive effect of androgen deprivation therapy on tumor recurrence. (2016)
  • Author(s): Izumi K, Ito Y, Miyamoto H, Miyoshi Y, Ota J, Moriyama M, Murai T, Hayashi H, Inayama Y, Ohashi K, Yao M, Uemura H.
  • Journal Title: Oncotarget Volume: 1 Issue: 12 Pages: 1-8
  • DOI: 10.18632/oncotarget.7358
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases. (2016)
  • Author(s): Miyoshi Y, Yoneyama S, Kawahara T, Hattori Y, Teranishi J, Kondo K, Moriyama M, Takebayashi S, Yokomizo Y, Yao M, Uemura H, Noguchi K.
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 128-128
  • DOI: 10.1186/s12885-016-2176-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer. (2016)
  • Author(s): Uemura K, Miyoshi Y, Kawahara T, Yoneyama S, Hattori Y, Teranishi J, Kondo K, Moriyama M, Takebayashi S, Yokomizo Y, Yao M, Uemura H, Noguchi K.
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 109-109
  • DOI: 10.1186/s12885-016-2160-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phosphoproteome analysis demonstrates the potential role of THRAP3 phosphorylation in androgen-independent prostate cancer cell growth. (2016)
  • Author(s): Ino Y, Arakawa N, Ishiguro H, Uemura H, Kubota Y, Hirano H, Toda T.
  • Journal Title: Proteomics Volume: 7 Pages: 1069-1078
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 前立腺癌におけるレニン・アンジオテンシン系の役割とARBの臨床的意義 (2016)
  • Author(s): 上村博司
  • Journal Title: Prostate Journal Volume: 3 Pages: 33-40
• [Journal Article] Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy. (2015)
  • Author(s): Kawahara T, Fukui S, Sakamaki K, Ito Y, Ito H, Kobayashi N, Izumi K, Yokomizo Y, Miyoshi Y, Makiyama K, Nakaigawa N, Yamanaka T, Yao M, Miyamoto H, Uemura H
  • Journal Title: Oncotarget Volume: 6(31) Issue: 31 Pages: 32169-32176
  • DOI: 10.18632/oncotarget.5081
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death. (2013)
  • Author(s): Sato A, Itcho N, Ishiguro H, Okamoto D, Kobayashi N, Kawai K, Kasai H, Kurioka D, Uemura H, Kubota Y, Watanabe M.
  • Journal Title: Int J Nanomedicine. Volume: 8 Pages: 3151-3160
  • DOI: 10.2147/ijn.s40766
  • Peer Reviewed
• [Journal Article] Angiotensin receptor blockers and risk of prostate cancer among United States veterans. (2013)
  • Author(s): Rao GA, Mann JR, Bottai M, Uemura H, Burch JB, Bennett CL, Haddock KS, Hébert JR.
  • Journal Title: J Clin Pharmacol Volume: 53 Issue: 7 Pages: 773-778
  • DOI: 10.1002/jcph.98
  • Peer Reviewed
• [Journal Article] Possible anti-tumor activity of initial treatment with zoledronic acid with hormonal therapy for bone-metastatic prostate cancer in multicenter clinical trial. (2013)
  • Author(s): Uemura H, Yanagisawa M, Ikeda I, Fujinami K, Iwasaki A, Noguchi S, Noguchi K, Kubota Y; Yokohama Bone Metastasis Study Group.
  • Journal Title: Int J Clin Oncol. Volume: 18 Issue: 3 Pages: 472-477
  • DOI: 10.1007/s10147-012-0406-8
  • Peer Reviewed
• [Journal Article] アンジオテンシンレセプターIIブロッカーの前立腺癌発生予防の実験的検証 (2013)
  • Author(s): 上村博司、伊藤悠亮、星野耕二、高橋智、窪田吉信
  • Journal Title: 日本腎泌尿器疾患予防医学研究会誌 Volume: 21 Pages: 103-105
• [Journal Article] Usefulness of Perflubutane Microbubble-Enhanced Ultrasound in Imaging and Detection of Prostate Cancer: Phase 2 Multicenter Clinical Trial (2012)
  • Author(s): Hiroji Uemura
  • Journal Title: World Journal of Urology Volume: 31 Issue: 5 Pages: 1123-1128
  • DOI: 10.1007/s00345-012-0833-1
  • Peer Reviewed
• [Presentation] Initial neutrophil-to-lymphocyte ratio (LNR) is a prognostic marker in penile cancer patients (2016)
  • Author(s): T Kawahara, J Kasuga, H Uemura, et al.
  • Organizer: AUA 2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Exploring novel biomarkers of specific castration resistant prostate cancer (CRPC) by the proteome analysis (2016)
  • Author(s): H Uemura, et al.
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-23
• [Presentation] Phase II clinical study of radium-223 chloride (BAY 88-8223) in Japanese patients with symptomatic castration-resistant prostate cancer (CRPC) with bone metastatsis. (2016)
  • Author(s): H Uemura, et al.
  • Organizer: ASCO-GU 2016
  • Place of Presentation: San Francisco
  • Year and Date: 2016-01-07
  • Int'l Joint Research
• [Presentation] Enhancement of anti-tumor activity by initial concurrent treatment with zoledronic acid and hormonal therapy for bone-metastatic prostate cancer in multicenter clinical trial.
  • Author(s): H Uemura, M Yanagisawa, I.Ikeda, K Fujinami, S.Noguchi, K Noguchi, Y Kubota, Yokohama Bone Metastasis Study Group,
  • Organizer: 米国泌尿器科学会総会
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Usefulness of contrast enhanced ultrasound in imaging and detection of prostate cancer
  • Author(s): Uemura H
  • Organizer: The 5th Asian conference on ultrasound contrast imaging,
  • Place of Presentation: 台北、中華民国
  • Invited
• [Presentation] 前立腺癌骨転移に対する新たな治療戦略
  • Author(s): 上村博司
  • Organizer: 第78回日本泌尿器科学会東部総会
  • Place of Presentation: 新潟コンベンションセンター（新潟県）
  • Invited
• [Presentation] Development of hormonal therapy, efficacy of GnRH antagonist.
  • Author(s): Uemura H
  • Organizer: 韓国泌尿器科学会総会
  • Place of Presentation: ソウル、韓国
  • Invited