Inhibitory effects of carbonic anhydrase 2 inhibitor on the invasion of urinary bladder cancer
| Project/Area Number |
25462499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka City University |
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Principal Investigator |
GI Min 大阪市立大学, 大学院医学研究科, 准教授 (70336783)
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| Co-Investigator(Kenkyū-buntansha) |
TAMADA Satoshi 大阪市立大学, 大学院医学研究科, 講師 (20382179)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膀胱癌 / 炭酸脱水酵素２阻害薬 / 炭酸脱水酵素２阻害剤 / carbonic anhydrase 2 / urinary bladder cancer / Invasion |
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| Outline of Final Research Achievements |
We have demonstrated that that carbonic anhydrase 2 (CA2) is an invasion-associated factor in urothelial carcinoma (UC). The purpose to the present study is to examine the inhibitory effects of CA inhibitor Acetazolamide (Ace) on the N-butyl-N-(hydroxybutyl)nitrosameine (BBN)-induced mouse urinary bladder carcinogenesis. We found that concurrent treatment with Ace and Cisplatin (Cis) significantly inhibited the development of BBN-induced UC. Moreover, muscle invasive UC were significantly decreased by the Ace alone and concurrent treatment with Ace and Cis. These findings indicate that CA could serve as a potential therapeutic molecular target for bladder cancers and suggest that CA inhibitors are useful for prevention of UC invasion.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] The role of deltaNp63pos CD44vpos cells in the development of NTCU-induced peripheral type of mouse lung squamous cell carcinomas..2016
Author(s)
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama S, Tachibana H, Ishii N, Fujioka M, Tatsumi K,Wanibuchi H.
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Journal Title
Cancer Sci
Volume: 107
Issue: 2
Pages: 123-132
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters2015
Author(s)
Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, Tachibana H, Tatsumi K, Fang H, Ishii N, Kakehashi A, Wanibuchi H.
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Journal Title
The Journal of Toxicological Sciences
Volume: 40
Issue: 5
Pages: 647-656
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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