The study of Endogenous vaccine effect by high-precision radiation therapy

• Project/Area Number: 25462500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kitasato University
• Principal Investigator: KUBO Makoto 北里大学, 医療衛生学部, 講師 (40464804)
• Co-Investigator(Kenkyū-buntansha): SATOH Takefumi 北里大学, 医学部, 准教授 (50286332) ; ISHIYAMA Hiromichi 北里大学, 医学部, 講師 (60343076)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 前立腺癌 / 放射線治療 / Endogenousワクチン / 免疫応答 / endogenous / vaccine

Outline of Final Research Achievements

Radiation therapy (RT) is one of the most important treatments for prostate cancer. Patients treated by RT were occasionally observed that metastatic cancer without directly radiation disappeared after RT treatment. RT might be able to induce effectively anti-tumor immunity. However, the details of immune responses were not clear in RT. Then, the lymphocyte subsets were analyzed by flow cytometry. The proportion of activated T cells in peripheral blood gradually increased after one of the RT treatment (low-dose-rate brachytherapy). RT treatment indicates to be inducible immune responses.

Research Products

• [Presentation] Analysis of immune responses in prostate cancer patients received low-dose-rate prostate brachyterapy (2015)
  • Author(s): KUBO Makoto, SATOH Takefumi, ISHIYAMA Hiromichi, TABATA Ken-ichi, TSUMURA Yasuhide, IGARASHI Yasuyuki, IWAMURA Masatsugu, BABA Shiro, HAYAKAWA Kazushige, OBATA Fumiya
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 北海道 札幌市 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Enhanced tumor antigen specific T cells in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration (2013)
  • Author(s): Kubo M, Satoh T, Tabata K, Matsumoto K, Yanagisawa N, Saegusa M, Okayasu I, Iwamura M, Baba S, Obata F
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Influence of LRRK2 G2019 mutation on peripheral B cells from Parkinson’s disease patients (2013)
  • Author(s): Rossi GR, Kubo M, Goncalves M, Rodrigues-Santos P, Januario C, Obata F, de Carvalho R, Souto-Carmerio M
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy