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Molecular mechanism of progression to castration resistant prostate cancer and its application for tailor made treatment

Research Project

Project/Area Number 25462503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionToho University

Principal Investigator

SUZUKI Hiroyoshi  東邦大学, 医学部, 教授 (60301818)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords前立腺癌 / 去勢抵抗性前立腺癌 / ERG / 予後予測モデル / PET / ドセタキセル / 酢酸アビラテロン / アンチアンドロゲン / アンドロゲン受容体 / 予測モデル / アビラテロン / PTEN / ホルモン療法
Outline of Final Research Achievements

To investigate the association of ERG expression, one of the most important molecular mechanism of progression to castration resistant prostate cancer (CRPC), with other molecular abnormalities, we examined specimens from radical prostatectomy, prostate biopsy, trans-urethral resection and autopsy. We examined the potential association of ERG expression and other gene abnormalities and clinical factors and found that ERG expression plays an important role of progression of CRPC. Especially, ERG expression was strongly related to PTEN expression.
Also, we examined prognostic factors for efficacy of each CRPC drugs and made statistical prognostic models (nomograms).
We have developed novel PET diagnostic drug reconizing amino acid tranportor and we attended the first global advanced prostate cancer conference held at St. Gallen, Switzland as a consensus panel member and debated about these new findings and other future CRPC treatment.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (34 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 12 results) Remarks (2 results)

  • [Int'l Joint Research] University of Tampere(フィンランド)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effect of androgen deprivation therapy on arterial stiffness and serum lipid profile changes in patients with prostate cancer: a prospective study of initial 6-month follow-up.2016

    • Author(s)
      Oka R, Utsumi T, Yano M, Kamijima S, Kamiya N, Shirai K, Suzuki H
    • Journal Title

      Int J Clin Oncol

      Volume: 21 Issue: 2 Pages: 389-396

    • DOI

      10.1007/s10147-015-0891-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of active surveillance criteria for pathologically insignificant prostate cancer in Asian men2016

    • Author(s)
      Yamada Y, Sakamoto S, Sazuka T, Goto Y, Kawamura K, Imamoto T, Nihei N, Suzuki H, Akakura K, Ichikawa T.
    • Journal Title

      Journal of Urology

      Volume: 23 Issue: 1 Pages: 49

    • DOI

      10.1111/iju.12952

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Diagnostic performance and safety of NMK36 (trans-1-Amino-3-[18F] fluorocyclobutanecarboxylic acid)-PET/CT in primary prostate cancer: Multicenter phase IIb clinical trial.2016

    • Author(s)
      Suzuki H, Inoue Y, Fujimoto H, Yonase J, Tanabe K, Fukasawa S, Inoue T, Saito S, Ueno M, Otaka A, Murakami K, Ishihara K, Kaji Y, Kuroki Y, Koizumi K, Yoshimura M, Takahashi H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 46 Issue: 2 Pages: 152-162

    • DOI

      10.1093/jjco/hyv181

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multi-center retrospective analysis of sequential treatment of abiraterone acetate followed by docetaxel in Japanese patients with metastatic castration-resistant prostate cancer.2015

    • Author(s)
      Ueda Y, Matsubara N, Takizawa I, Nishiyama T, Yabata K, Satoh T, Kamiya N, Suzuki H, Kawahara T, Uemura H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 45 Issue: 8 Pages: 774-779

    • DOI

      10.1093/jjco/hyv070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of patients with advanced prostate cancer: Recommendations of the St.Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.2015

    • Author(s)
      Gillessen S, Omlin A, Attard G, de Bono JS, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM, Beltran H, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B
    • Journal Title

      Ann Oncol

      Volume: 26 Issue: 8 Pages: 1589-1604

    • DOI

      10.1093/annonc/mdv257

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] External validation and comparison of two nomograms predicting the probability of Gleason sum upgrading between biopsy and radical prostatectomy pathology in two patient populations: a retrospective cohort study.2015

    • Author(s)
      Utsumi T, Oka R, Endo T, Yano M, Kamijima S, Kamiya N, Fujimura M, Sekita N, Mikami K, Hiruta N,Suzuki H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 45 Issue: 11 Pages: 1091-1095

    • DOI

      10.1093/jjco/hyv128

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Nadir Testosterone after Long-Term Followup Predicts Prognosis in Patients with Prostate Cancer Treated with Combined Androgen Blockade.2015

    • Author(s)
      Kamada S, Sakamoto S, Ando K, Muroi A, Fuse M, Kawamura K, Imamoto T, Suzuki H, Nagata M, Nihei N, Akakura K, Ichikawa T.
    • Journal Title

      Journal of Urology

      Volume: 194 Issue: 5 Pages: 1264-70

    • DOI

      10.1016/j.juro.2015.03.120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Health-related quality of life after carbon-ion radiotherapy for prostate cancer: A 3-year prospective study.2014

    • Author(s)
      Katoh H, Tsuji H, Ishikawa H, Kamada T, Wakatsuki M, Hirasawa N, Suzuki H, Akakura K, Nakano T, Shimazaki J, Tsujii H.
    • Journal Title

      Int J Urol.

      Volume: 21 Issue: 4 Pages: 370-5

    • DOI

      10.1111/iju.12294

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of PTEN is associated with aggressive behavior in ERG positive prostate cancer2014

    • Author(s)
      Leinonen KA, Saram臾i OR, Furusato B, Kimura T, Takahashi H, Egawa S, Suzuki H, Keiger K, Hahm SH, Isaacs WB, Tolonen TT, Stenman UH, Tammela TLJ, Nykter M, Bova GS, Visakorpi T
    • Journal Title

      Cancer Epidemiol Biomarkers Prev

      Volume: 印刷中 Issue: 12 Pages: 2333-2344

    • DOI

      10.1158/1055-9965.epi-13-0333-t

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of nomogram to non-steroidal antiandrogen sequential alternation in prostate cancer for predictive model.2014

    • Author(s)
      Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Issue: 3 Pages: 263-269

    • DOI

      10.1093/jjco/hyt230

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of J-CAPRA Score for High-risk Prostate Cancer Patients Treated with Carbon Ion Radiotherapy Plus Androgen Deprivation Therapy.2014

    • Author(s)
      Akakura K, Tsuji H, Suzuki H, Ichikawa T, Ishikawa H, Okada T, Kamada T, Harada M, Tsujii H, Shimazaki J.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Issue: 4 Pages: 360-5

    • DOI

      10.1093/jjco/hyu006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration-resistant prostate cancer: A retrospective multi-institutional collaborative study2013

    • Author(s)
      Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T.
    • Journal Title

      Int J Clin Oncol.

      Volume: 19 Issue: 1 Pages: 157

    • DOI

      10.1007/s10147-012-0510-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 前立腺癌診断のこれまでとこれから:『プロメーテウスの火』としてのPSA2016

    • Author(s)
      鈴木啓悦
    • Organizer
      第620回日本泌尿器科学会東京地方会
    • Place of Presentation
      御茶ノ水ソラシティ(東京都・千代田区)
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 日本の進行性前立腺癌治療を考える:ガラパゴス化とグローバル化2015

    • Author(s)
      鈴木啓悦
    • Organizer
      第29回日本泌尿器内視鏡学会総会
    • Place of Presentation
      京王プラザホテル東京(東京都・新宿区)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アンドロゲン環境から前立腺癌治療を考える:草食系男子と肉食系男子で治療は違うのか?2015

    • Author(s)
      鈴木啓悦
    • Organizer
      第67回日本泌尿器科学会西日本総会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 前立腺癌骨転移:Bone-dominant diseaseを考える2015

    • Author(s)
      鈴木啓悦
    • Organizer
      日本泌尿器腫瘍学会第1回学術集会
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 去勢抵抗性前立腺癌の最適化治療:新規薬剤の開発2015

    • Author(s)
      鈴木啓悦,内海孝信,遠藤匠,岡了,李芳菁,加藤精二,宋本尚俊,若井健,西見大輔,高波眞佐治,矢野仁,上島修一,神谷直人
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Assessment of Arterial Stiffness Using Cardio-Ankle Vascular Index in Patients with Prostate Cancer Treated by a Short-Term of Androgen Deprivation Therapy.2015

    • Author(s)
      Oka R, Utumi T, Kamiya N, Lee F, Endo T, Yano M, Kamijima S, Nishimi D, Takanami M, Suzuki H
    • Organizer
      SIU2015
    • Place of Presentation
      Melbourne, Victoria, Australia
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcriptionally-Targeted Retroviral Replicating Vectors: A Novel Strategy for Gene Therapy of Prostate Caner.2015

    • Author(s)
      Kamijima S, Kimura T, Inagaki A, Hiraoka K, Haga K, Collins S, Hermann K, Kamiya N, Hacke K, Logg C, Kao C, Bochner B, Kasahara N, Suzuki H
    • Organizer
      SIU2015
    • Place of Presentation
      Melbourne, Victoria, Australia
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドセタキセルのエビデンスと最適な患者像とは?2015

    • Author(s)
      神谷直人,内海孝信,遠藤匠,矢野仁,上島修一,西見大輔,高波眞佐治,鈴木啓悦
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      京王プラザホテル東京(東京都・新宿区)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nadir Testosterone after Long-Term Follow-Up Predicts Prognosis of Prostate Cancer Patients Treated With Combined Androgen Blockade.2015

    • Author(s)
      Shuhei Kamada, Shinichi Sakamoto, Keisuke Ando, Ayumi Muroi, Miki Fuse, Koji Kawamura, Takashi Imamoto, Hiroyoshi Suzuki, Maki Nagata, Naoki Nihei, Koichiro Akakura, Tomohiko Ichikawa
    • Organizer
      America Urological Association Annual Meeting 2015
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 進行性前立腺癌に対する骨マネジメント2015

    • Author(s)
      鈴木啓悦
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      ホテル金沢(石川県・金沢市)
    • Year and Date
      2015-04-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Men’s Bone Healthを考える2015

    • Author(s)
      鈴木啓悦
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(石川県・金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 日本人の日本人による日本人のためのCRPC治療を考える2015

    • Author(s)
      鈴木啓悦
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 前立腺がんにおけるホルモン療法のパラダイム・シフト

    • Author(s)
      鈴木啓悦
    • Organizer
      がんセンター・多地点合同メディカル・カンファレンス
    • Place of Presentation
      茨城県笠間市 茨城県立中央病院
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 病期C前立腺癌症例に対するホルモン療法併用放射線療法

    • Author(s)
      鈴木啓悦,岡了,李芳菁,内海孝信,遠藤匠,矢野仁,直井牧人,上島修一,西見大輔,高波眞佐治,神谷直人
    • Organizer
      第78回日本泌尿器科学会東部総会
    • Place of Presentation
      新潟県新潟市  朱雀メッセ
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Validation of active surveillance criteria for pathological insignificant prostate cancer in Japanese men

    • Author(s)
      Yamada Y, Sakamoto S, Sazuka T, Goto Y, Yanagisawa M, Kawamura K, Kamiya N, Imamoto T, Nihei N, Suzuki H, Sato N, Ichikawa T
    • Organizer
      The 4th congress of Asian Pacific Prostate Society
    • Place of Presentation
      沖縄県那覇市 万国津梁館
    • Related Report
      2013 Research-status Report
  • [Presentation] Prodrug-activator gene therapy using prostate-targeted retroviral replicating vectors

    • Author(s)
      Kamijima S, Kimura T, Haga K, Hiraoka K, Inagaki A, Tam Q, Logg CR, Kao C, Bochner BH, Suzuki H, Kasahara N, Ichikawa T
    • Organizer
      The 4th congress of Asian Pacific Prostate Society
    • Place of Presentation
      沖縄県那覇市 万国津梁館
    • Related Report
      2013 Research-status Report
  • [Presentation] Prostate cancer sequencing: Locally advanced prostate cancer

    • Author(s)
      Suzuki H
    • Organizer
      The 4th congress of Asian Pacific Prostate Society
    • Place of Presentation
      沖縄県那覇市  万国津梁館
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy with castration-resistant prostate cancer: A retrospective multi-institutional collaborative study

    • Author(s)
      Kamiya N, Suzuki H, Ueda T, Nakatsu H, Sato N, Mikami K, Sato N, Ichikawa T
    • Organizer
      American Urological Association Annual meeting
    • Place of Presentation
      米国San Diego Convention Center
    • Related Report
      2013 Research-status Report
  • [Remarks] 東邦大学医療センター佐倉病院泌尿器科

    • URL

      http://www.lab.toho-u.ac.jp/med/sakura/urology/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東邦大学医療センター佐倉病院泌尿器科ホームページ

    • URL

      http://www.lab.toho-u.ac.jp/med/sakura/urology/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-01-27  

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