Plastic changes in transmission of neuropeptide and metabotropic glutamate related to voiding dysfunction after chronic spinal cord injury
| Project/Area Number |
25462507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIRA Satoru 山梨大学, 総合研究部, 助教 (10530115)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 下部尿路機能 / 膀胱 / 外尿道括約筋 / マウス / 排尿障害 / 脊髄損傷 / 興奮性グルタミン酸受容体 / 神経ペプチド / 外尿道括約筋活動 / 膀胱活動 / 下部尿路機能制御 / 慢性脊髄損傷 / 代謝型グルタミン酸 |
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| Outline of Final Research Achievements |
We compared the lower-urinary-tract function of the wild type (WT) spinal cord injured mouse and the metabotropic glutamate receptor subtype 1a (mGluR1a-KO) gene deficit spinal cord injured mouse, using a cystometrogram and external urethral sphincter (EUS) electromyogram (EMG). The mGluR1a-KO presented more marked detrusor-sphincter dyssynergia (DSD) compared with WT. The mGluR5 antagonist increased the occurrence rate of DSD in the WT spinal cord injured mouse. The above results suggest that the neural transmission via mGluR1a and mGluR5 is involved in anti-DSD in urinary voiding dysfunction after spinal cord injury.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Expression of large conductance, voltage- and Ca2+-activated K+ (BK) channels in human urinary bladder: alteration of subunit expression profile in association with bladder outlet obstruction2013
Author(s)
Zakoji, H., Kobayashi, H., Yoshiyama, M., Takeda, M., Araki, I.
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Journal Title
Open Journal of Urology
Volume: 3
Issue: 02
Pages: 47-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Distribution and possible function of cannabinoid receptor subtype 1 in the human prostate2013
Author(s)
Kamiyama, M., Fukasawa, M., Takihana, Y., Sawada, N., Nakagomi, H., Yoshiyama, M., Araki, I., Takeda, M.
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Journal Title
Open Journal of Urology
Volume: 3
Issue: 02
Pages: 102-109
DOI
Related Report
Peer Reviewed
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[Presentation] Clock genes regulate circadian rhythm of Piezo1 and TRPV4 expressions and intracellular Ca2+ influx after stretch stimulation in the cultured urothelial cells2016
Author(s)
Tatsuya Ihara,Satoru Kira,Tatsuya Miyamoto,Norifumi Sawada,Hiroshi Nakagomi,Takahiko Mitsui,Hideki Kobayashi,Mitsuharu Yoshiyama,Masayuki Takeda,Yuki Nakamura,Atsuhito Nakao,Eiji Shigetomi,Keisuke Shibata,Youichi Shinozaki,Syuichi Koizumi
Organizer
The 31st Annual Congress of the European Association of Urology
Place of Presentation
Munich, Germany
Year and Date
2016-03-13
Related Report
Int'l Joint Research
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