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Functional roles of fascia of external urethra sphincters in recovery of continence and cell sheet engineering

Research Project

Project/Area Number 25462508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionShinshu University

Principal Investigator

KATO Haruaki  信州大学, 医学部附属病院, 特任研究員 (90233808)

Co-Investigator(Kenkyū-buntansha) IMAMURA Tetsuya  信州大学, 医学部, 特任講師 (00467143)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords尿失禁 / 外尿道括約筋筋膜 / 骨髄由来細胞 / 脂肪由来細胞 / 細胞シート / ウサギ / 尿道括約筋筋膜 / 組織工学 / 尿道再生
Outline of Final Research Achievements

This study investigated the functional roles of fascia of external urethra sphincters in recovery of continence. And then, this study determined if bone marrow- or adipose-derived cell sheets that imitated the fascia could recover the continence. We attempted to produce injured fascia of external urethra sphincters in rabbits. However, we could not identify the fascia that was similar to the one in human. Thus, we injured external urethra sphincters with the monopolar. Finally, we transplanted cell sheets on the injured regions, and investigated the recovery of functional urethra.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Novel insight for midline cyst formation in prostate: The involvement of decreased prenatal testosterone suggested by second-to-forth digit ratio study2015

    • Author(s)
      Furuya S, Hisasue S, Kato H, Shimamura S
    • Journal Title

      International Journal of Urology

      Volume: 22 Issue: 11 Pages: 1063-1067

    • DOI

      10.1111/iju.12892

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 膀胱膣瘻(尿路再建術の適応と手技)2015

    • Author(s)
      加藤晴朗
    • Journal Title

      泌尿器外科

      Volume: 28 Pages: 417-419

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 尿路直腸瘻の治療法-膀胱瘻の有用性-2015

    • Author(s)
      羽場知己、小池 宏、加藤晴朗
    • Journal Title

      泌尿器外科

      Volume: 28 Pages: 421-430

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineered bone marrow-derived cell sheets restore structure and function of radiation-injured rat urinary bladder2015

    • Author(s)
      Imamura T, Ogawa T, Minagawa T, Yokoyama H, Nakazawa M, Nishizawa O, Ishizuka O
    • Journal Title

      Tissue Engineering Part A

      Volume: 21 Issue: 9-10 Pages: 1600-1610

    • DOI

      10.1089/ten.tea.2014.0592

    • NAID

      120007100146

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Implantation of adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra2014

    • Author(s)
      Gautam S S, Imamura T, Ishizuka O, Zhang L, Yamagishi T, Yokoyama H, Minagawa T, Ogawa T, Kurizaki Y, Kato H, Nishizawa O
    • Journal Title

      Tissue Engineering Part A

      Volume: 20 Issue: 13-14 Pages: 1971-1979

    • DOI

      10.1089/ten.tea.2013.0491

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 前立腺全摘後の吻合部狭窄および瘢痕化(いわゆるdevastated bladder outlet) 前立腺全摘後の合併症-予防と対処2013

    • Author(s)
      加藤晴朗、西澤 理
    • Journal Title

      臨床泌尿器科

      Volume: 67 Pages: 209-214

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 尿道損傷2013

    • Author(s)
      加藤晴朗
    • Journal Title

      泌尿器科診療ベストNAVI

      Volume: 67 Pages: 120-122

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膀胱損傷2013

    • Author(s)
      加藤晴朗
    • Journal Title

      泌尿器科診療ベストNAVI

      Volume: 67 Pages: 123-125

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膀胱膣瘻・尿管損傷・尿管膣瘻2013

    • Author(s)
      加藤晴朗
    • Journal Title

      泌尿器科診療ベストNAVI

      Volume: 67 Pages: 126-127

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 経会陰手術とロボット支援下内視鏡手術併用で再吻合したいわゆる Devastated Outlet の1例2016

    • Author(s)
      加藤晴朗
    • Organizer
      第8回日本ロボット外科学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 創造的な手術を生みだすために2013

    • Author(s)
      加藤晴朗
    • Organizer
      東北地方会ランチョンセミナー
    • Place of Presentation
      仙台 宮城
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 外傷性後部尿道断裂および医原性後部尿道断裂に対する後部尿道形成術の成績2013

    • Author(s)
      加藤晴朗
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      横浜 神奈川
    • Related Report
      2013 Research-status Report
  • [Presentation] 機能的単腎に対する外傷性尿管断裂の治療2013

    • Author(s)
      加藤晴朗
    • Organizer
      第27回日本外傷学会
    • Place of Presentation
      久留米 福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 前立腺全摘除術~いかに合併症を克服するか~2013

    • Author(s)
      加藤晴朗
    • Organizer
      静岡市泌尿器科医会
    • Place of Presentation
      静岡 静岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 尿道狭窄 最近の動向2013

    • Author(s)
      加藤晴朗
    • Organizer
      第48回関西泌尿器セミナー
    • Place of Presentation
      大阪 大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Creativeな手術とChallengingな手術2013

    • Author(s)
      加藤晴朗
    • Organizer
      富山県泌尿器科医会学術講演会
    • Place of Presentation
      富山 富山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Continent valve for devastated outlet using a bulbar urethra2013

    • Author(s)
      加藤晴朗
    • Organizer
      Asia-Europe academic forum for urinary tract repair and reconstruction
    • Place of Presentation
      上海 中国
    • Related Report
      2013 Research-status Report
  • [Presentation] 外傷性後部尿道断裂に対する後部尿道形成術の成績2013

    • Author(s)
      加藤晴朗
    • Organizer
      第78回日本泌尿器科学会東部総会
    • Place of Presentation
      新潟 新潟
    • Related Report
      2013 Research-status Report
  • [Presentation] ロボット時代に前立腺全摘術において開放手術の教育は必要か?必要である ディベート2013

    • Author(s)
      加藤晴朗
    • Organizer
      第27回日本泌尿器内視鏡学会総会
    • Place of Presentation
      名古屋 愛知
    • Related Report
      2013 Research-status Report
  • [Presentation] 外傷性および医原性の後部尿道病変の治療2013

    • Author(s)
      加藤晴朗
    • Organizer
      第8回東北信泌尿器科手術手技カンファレンス
    • Place of Presentation
      長野 長野
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 瘻孔閉鎖術(膀胱膣瘻、膀胱直腸瘻を中心に)新版 泌尿器科周術期管理のすべて2013

    • Author(s)
      加藤晴朗
    • Total Pages
      8
    • Publisher
      メジカルビュー社
    • Related Report
      2013 Research-status Report
  • [Remarks] 連載コラム:図脳を極める

    • URL

      http://pfizerpro.jp/cs/sv/detrusitol/column/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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