Surveillance of antimicrobial susceptibility of pathogens of male urethritis
| Project/Area Number |
25462509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gifu University |
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Principal Investigator |
Deguchi Takaashi 岐阜大学, 医学(系)研究科(研究院), 教授 (40163935)
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| Co-Investigator(Kenkyū-buntansha) |
YSUDA Mitsuru 岐阜大学, 医学部附属病院, 講師 (90311703)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Neisseria gonorrhoeae / Mycoplasma genitalium / 薬剤耐性 / 性感染症 / 尿道炎 / Mycoplasma gentialium / ceftriaxone / azithromycin / fluoroquinolone / 23S rRNA / parC / gyrA |
|---|
| Outline of Final Research Achievements |
We examined clinical isolates of Neisseria gonorrhoeae for antimicrobial susceptibility and Mycoplasma genitalium DNAs for macrolide and quinolone resistance-associated mutations. We observed some isolates with decreased susceptibility to cefixime, with resistance to levofloxacin, and with resistance to azithromycin. We isolated a strain (GU140106) with decreased to ceftriaxone in 2014 but found that all other isolates were susceptible to ceftriaxone. We detected macrolide resistance-associated and/or quinolone resistance-associated mutations in M. genitalium DNAs. The presence of M. genitalium DNAs harboring both mutations suggested that some strains of M. genitalium might be evolving into multi-drug resistant ones. We should continue to pay attention to the antimicrobial susceptibility of these pathogens.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] New Clinical Strain of Neisseria gonorrhoeae with Decreased Susceptibility to Ceftriaxone, Japan.2016
Author(s)
Deguchi T, Yasuda M, Hatazaki K, Kameyama K, Horie K, Kato T, Mizutani K, Seike K, Tsuchiya T, Yokoi S, Nakano M, Yoh M.
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Journal Title
Emerging infectious diseases
Volume: 22
Issue: 1
Pages: 142-144
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Drug resistance-associated mutations in Mycoplasma genitalium in female sex workers, Japan.2015
Author(s)
Deguchi T, Yasuda M, Horie K, Seike K, Kikuchi M, Mizutani K, Tsuchiya T, Yokoi S, Nakano M, Hoshina S.
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Journal Title
Emerging infectious diseases
Volume: 21
Issue: 6
Pages: 1062-1064
DOI
Related Report
Peer Reviewed / Open Access
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