Research for urinary tract infection-causative carbapemase-producing bacteria
| Project/Area Number |
25462512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kobe University |
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Principal Investigator |
Shigemura Katsumi 神戸大学, 医学(系)研究科(研究院), 病院講師 (00457102)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKAWA Soichi 神戸大学, 大学院医学研究科腎泌尿器科学分野, 特命教授 (70159490)
TANAKA Kazushi 神戸大学, 大学院医学研究科腎泌尿器科学分野, 特命教授 (20335433)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 尿路感染症 / 泌尿器科学 / カルバペネマーゼ産生菌 / 薬剤耐性菌 |
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| Outline of Final Research Achievements |
Production of metallo-beta-lactamase (MBL) which is known as a class B carbapenemase-producing bacteria were investigated and MBL occupied 84.6 % in all CRE strains. All the bacteria were categorized as IMP-6 by sequencing. As to the bacteria other than Enterobacteriaceae, MBL producing bacteria occupied 76.4% in all the carbapenem-resistant Pseudomonas aeruginosa and sequencing data showed that IMP type was in 85.7%（IMP-1 type: 55.6% and IMP-7 type: 44.4%）and VIM type was 9.5%. Regarding epidemiological analysis, repetitive extragenic palindromic sequence (rep)-PCR data showed that 72 strains of extended-spectrum β-lactamases (ESBLs) producing Escherichia coli were categorized into 18 groups. The reproducibility of this method using ESBL producing strains may lead to further application for carbapenemase-producing bacteria.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Molecular Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli in a University Teaching Hospital.2015
Author(s)
Osawa K, Shigemura K, Shimizu R, Kato A, Kusuki M, Jikimoto T, Nakamura T, Yoshida H, Arakawa S, Fujisawa M, Shirakawa T.
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Journal Title
Microb Drug Resist.
Volume: 21
Issue: 2
Pages: 130-139
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antimicrobial resistance in Salmonella strains clinically isolated in Hyogo, Japan (2009-2012).2014
Author(s)
Osawa K, Shigemura K, Shimizu R, Kato A, Kimura M, Katayama Y, Okuya Y, Yutaka S, Nishimoto A, Kishi A, Fujiwara M, Yoshida H, Iijima Y, Fujisawa M, Shirakawa T.
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Journal Title
Jpn J Infect Dis.
Volume: 67
Pages: 54-57
NAID
Related Report
Peer Reviewed
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