| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Production of metallo-beta-lactamase (MBL) which is known as a class B carbapenemase-producing bacteria were investigated and MBL occupied 84.6 % in all CRE strains. All the bacteria were categorized as IMP-6 by sequencing. As to the bacteria other than Enterobacteriaceae, MBL producing bacteria occupied 76.4% in all the carbapenem-resistant Pseudomonas aeruginosa and sequencing data showed that IMP type was in 85.7%（IMP-1 type: 55.6% and IMP-7 type: 44.4%）and VIM type was 9.5%. Regarding epidemiological analysis, repetitive extragenic palindromic sequence (rep)-PCR data showed that 72 strains of extended-spectrum β-lactamases (ESBLs) producing Escherichia coli were categorized into 18 groups. The reproducibility of this method using ESBL producing strains may lead to further application for carbapenemase-producing bacteria.
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