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The role of sensory neuron-specific receptor in the regulation of micturition reflex

Research Project

Project/Area Number 25462513
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionTottori University

Principal Investigator

HONDA Masashi  鳥取大学, 医学部附属病院, 講師 (20362890)

Co-Investigator(Kenkyū-buntansha) TAKENAKA Atsushi  鳥取大学, 医学部, 教授 (50368669)
SAITO Motoaki  高知大学, 医歯学系, 教授 (60273893)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords下部尿路機能障害 / 新規受容体 / SNSR / シクロホスファミド誘発膀胱炎 / 膀胱内圧測定 / 膀胱内注入 / 下部尿路機能
Outline of Final Research Achievements

A novel family of G-protein-coupled receptors has been identified in rat dorsal root ganglia and named as sensory neuron-specific receptors (SNSRs). Intravenous or intrathecal administration of BAM8-22, a selective rat SNSR1 agonist, can suppress cyclophosphamide-induced bladder overactivity, probably due to suppression of bladder afferent activity. In urethane-anesthetized rats, intravesical administration of BAM8-22 can ameliorate cyclophosphamide-induced bladder overactivity via suppression of capsaicin sensitive C-fiber afferent pathways in rats. Thus, SNSRs could be an effective target for the treatment of bladder dysfunction such as overactive bladder and bladder pain syndrome/interstitial cystitis, for which C-fiber afferent hyperexcitability has been proposed to be an important pathophysiological basis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2013

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Intravesical administration of sensory neuron-specific receptor agonist suppresses cyclophophamide-induced bladder overactivity2016

    • Author(s)
      Honda M, Yoshimura N, Kawamoto B, Panagiota T, Shimizu S, Morizane S, Hikita K, Muraoka K, Shimizu T, Sejima T, Saito M, Chancellor MB, Takenaka A
    • Organizer
      American Urological Association Annual Meeting 2016
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2016-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cyclophosphamide誘発膀胱過活動に対するsensory neuron-specific receptor agonistの効果2013

    • Author(s)
      本田正史、吉村直樹、川本文弥、井上誠也、引田克弥、日向信之、村岡邦康、Tsounapi Panagiota、磯山忠広、瀬島健裕、Michael Chancellor、武中 篤
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館 北海道 札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] Inhibitory effects of intravesical administration of sensory neuron-specific receptor agonist on the micturition reflex in rats2013

    • Author(s)
      Honda M, Yoshimura N, Kawamoto B, Inoue S, Kobayashi N, Hikita K, Muraoka K, Saito M, Chancellor M, Sejima T, Takenaka A
    • Organizer
      43rd Annual Meeting of the International Continence Society
    • Place of Presentation
      Centre Convencions Internacional de Barcelona, Barcelona, Spain
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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