The role of sensory neuron-specific receptor in the regulation of micturition reflex
Project/Area Number |
25462513
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Tottori University |
Principal Investigator |
HONDA Masashi 鳥取大学, 医学部附属病院, 講師 (20362890)
|
Co-Investigator(Kenkyū-buntansha) |
TAKENAKA Atsushi 鳥取大学, 医学部, 教授 (50368669)
SAITO Motoaki 高知大学, 医歯学系, 教授 (60273893)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 下部尿路機能障害 / 新規受容体 / SNSR / シクロホスファミド誘発膀胱炎 / 膀胱内圧測定 / 膀胱内注入 / 下部尿路機能 |
Outline of Final Research Achievements |
A novel family of G-protein-coupled receptors has been identified in rat dorsal root ganglia and named as sensory neuron-specific receptors (SNSRs). Intravenous or intrathecal administration of BAM8-22, a selective rat SNSR1 agonist, can suppress cyclophosphamide-induced bladder overactivity, probably due to suppression of bladder afferent activity. In urethane-anesthetized rats, intravesical administration of BAM8-22 can ameliorate cyclophosphamide-induced bladder overactivity via suppression of capsaicin sensitive C-fiber afferent pathways in rats. Thus, SNSRs could be an effective target for the treatment of bladder dysfunction such as overactive bladder and bladder pain syndrome/interstitial cystitis, for which C-fiber afferent hyperexcitability has been proposed to be an important pathophysiological basis.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] Intravesical administration of sensory neuron-specific receptor agonist suppresses cyclophophamide-induced bladder overactivity2016
Author(s)
Honda M, Yoshimura N, Kawamoto B, Panagiota T, Shimizu S, Morizane S, Hikita K, Muraoka K, Shimizu T, Sejima T, Saito M, Chancellor MB, Takenaka A
Organizer
American Urological Association Annual Meeting 2016
Place of Presentation
San Diego Convention Center, San Diego, USA
Year and Date
2016-05-06
Related Report
Int'l Joint Research
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[Presentation] Inhibitory effects of intravesical administration of sensory neuron-specific receptor agonist on the micturition reflex in rats2013
Author(s)
Honda M, Yoshimura N, Kawamoto B, Inoue S, Kobayashi N, Hikita K, Muraoka K, Saito M, Chancellor M, Sejima T, Takenaka A
Organizer
43rd Annual Meeting of the International Continence Society
Place of Presentation
Centre Convencions Internacional de Barcelona, Barcelona, Spain
Related Report