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Studies on Lactobacillus probiotics for refractory or recurrent urinary tract infections

Research Project

Project/Area Number 25462514
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionOkayama University

Principal Investigator

ISHII AYANO  岡山大学, 大学病院, 准教授 (00423294)

Co-Investigator(Kenkyū-buntansha) 和田 耕一郎  岡山大学, 大学病院, 講師 (20423337)
狩山 玲子  岡山学院大学, 人間生活学部, 准教授 (40112148)
Co-Investigator(Renkei-kenkyūsha) KUMON Hiromi  岡山大学, 医歯薬学総合研究科, 特命教授 (30144760)
Research Collaborator YAMAMOTO Masumi  
MITSUHATA Ritsuko  
HORI Kenji  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords尿路感染症 / プロバイオティクス / 乳酸菌 / バイオフィルム / 緑膿菌 / 大腸菌 / MRSA
Outline of Final Research Achievements

For patients with refractory or recurrent urinary tract infections, it is required to develop new preventive and therapeutic strategies other than antimicrobial therapy. Therefore, as a clinical study, we evaluated the effectiveness of Lactobacillus vaginal suppositories with high hydrogen peroxide producing ability against patients with refractory or recurrent urinary tract infections. On the other hand, in basic experiments, this L. crispatus strain inhibited biofilm formation of Pseudomonas aeruginosa, Escherichia coli, MRSA. In addition, the inhibitory effects of this L. crispatus strain against P. aeruginosa, E. coli, MRSA were enhanced by using antimicrobial agents.
It was suggested that Lactobacillus probiotics are useful as a preventive and therapeutic strategy other than antimicrobial therapy for refractory or recurrent urinary tract infections.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (6 results)

  • [Journal Article] A phaseⅡclinical trial evaluating the preventive effectiveness of lactobacillus vaginal suppositories in patients with recurrent cystitis2016

    • Author(s)
      Wada K., Uehara S., Ishii A., Sadahira T., Yamamoto M., Mitsuhata R., Takamoto A., Araki M., Kobayashi Y., Watanabe M., Watanabe T., Hotta K., Nasu Y
    • Journal Title

      Acta Med Okayama

      Volume: 70 Pages: 299-302

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 緑膿菌バイオフィルムに対する乳酸菌プロバイオティクスの基礎的検討2015

    • Author(s)
      狩山玲子、光畑律子、石井亜矢乃、和田耕一郎、公文裕巳
    • Journal Title

      Bacterial Adherence & Biofilm

      Volume: 28 Pages: 41-45

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 泌尿器科領域における緑膿菌感染症の治療戦略-基礎的アプローチ2015

    • Author(s)
      狩山玲子、公文裕巳
    • Journal Title

      緑膿菌感染症研究会講演記録

      Volume: 49 Pages: 39-41

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Molecular epidemiology and clinical implications of metallo-β-lactamase-producing Pseudomonas aeruginosa isolated from urine2014

    • Author(s)
      Sako S, Kariyama R, Mitsuhata R, Yamamoto M, Wada K, Ishii A, Uehara S , Kogeguchi S, Kusano N and Kumon H
    • Journal Title

      Acta Medica Okayama

      Volume: 68 Pages: 89-99

    • NAID

      120005425630

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 尿路バイオフィルム感染症に対する 乳酸菌プロバイオティクスに関する基礎的検討2016

    • Author(s)
      光畑 律子、狩山 玲子、山本 満寿美、和田 耕一郎、石井 亜矢乃、渡辺豊彦、那須保友
    • Organizer
      第86回日本感染症学会西日本地方会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳酸菌膣坐剤の膀胱炎再発抑制効果に関する臨床的検討2016

    • Author(s)
      石井亜矢乃、山本満寿美、定平卓也、和田耕一郎、渡辺豊彦、狩山玲子、上原慎也、門田晃一、那須保友、公文裕巳
    • Organizer
      第64回日本化学療法学会西日本支部総会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頻回再発性膀胱炎に対する乳酸菌膣坐剤の臨床効果2016

    • Author(s)
      石井亜矢乃、山本満寿美、光畑律子、定平卓也、和田耕一郎、渡辺豊彦、狩山玲子、上原慎也、門田晃一、公文裕巳、那須保友
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頻回再発性膀胱炎に対する乳酸菌膣坐剤の予防効果に関する臨床的検討2015

    • Author(s)
      石井亜矢乃、山本満寿美、和田耕一郎、渡辺豊彦、狩山玲子、上原慎也、公文裕巳
    • Organizer
      第85回日本感染症学会西日本地方会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム甍(奈良市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 緑膿菌バイオフィルム形成に及ぼす乳酸菌の抑制効果について

    • Author(s)
      光畑律子
    • Organizer
      第88回日本感染症学会学術講演会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 岡山大学泌尿器科における尿中分離菌および薬剤感受性の動向~30年間の変遷~

    • Author(s)
      山本満寿美
    • Organizer
      第62回日本化学療法学会総会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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