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Functional analysis of urinary stone formation to target the mitochondrial membrane and its application to prophylaxis

Research Project

Project/Area Number 25462520
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

Endo Sumio  名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30646823)

Co-Investigator(Kenkyū-buntansha) Kohri Kenjiro  名古屋市立大学, 学長 (30122047)
Yasui Takahiro  名古屋市立大学, 大学院医学研究科, 教授 (40326153)
Okada Atsushi  名古屋市立大学, 大学院医学研究科, 講師 (70444966)
Niimi Kazuhiro  名古屋市立大学, 大学院医学研究科, 研究員 (70551274)
Research Collaborator Ito Yasuhiko  名古屋市立大学, 大学院医学研究科, 研究員
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords尿路結石 / cyclophilin D / ミトコンドリア / 酸化ストレス
Outline of Final Research Achievements

In this study by using the cyclophilin D deficient mice, we elucidate the effect of cyclophilin D to the formation of urinary tract stones in initial step at the molecular level, and aimed at the development of a prophylactic agent of urinary tract stones by inactivation of cyclophilin D.
When the oxidative stress such as oxalic acid stimulation applies to renal tubular cells, cyclophilin D is active and mitochondria collapse. This promotes oxidative stress and formation of urinary tract stone, we elucidat. So we prove inactivation of cyclophilin D suppress urinary stone formation. We think that it is a study that leads to the development of preventive medicine of the urinary stone.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Proinflammatory and Metabolic Changes Facilitate Renal Crystal Deposition in an Obese Mouse Model of Metabolic Syndrome.2015

    • Author(s)
      Taguchi K, Okada A, Hamamoto S, Iwatsuki S, Naiki T, Ando R, Mizuno K, Tozawa K, Kohri K, Yasui T.
    • Journal Title

      J Urol.

      Volume: 194 Issue: 6 Pages: 1787-96

    • DOI

      10.1016/j.juro.2015.07.083

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Mitochondrial collapse depends on Cyclophillin D in renal tubular cells promotes kidney stone formation.2015

    • Author(s)
      Ito Yasuhiko, Niimi Kazuhiro, Yasui Takahiro, Okada Atsushi, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting 2015
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cyclophilin D欠損マウスを用いた尿路結石形成におけるミトコンドリア傷害機序の解明2015

    • Author(s)
      伊藤 靖彦、安井 孝周、新美 和寛、岡田 淳志、郡 健二郎
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢 他(金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cyclophilin D欠損マウスを用いた尿路結石形成における2013

    • Author(s)
      伊藤靖彦
    • Organizer
      日本尿路結石症学会 第23回学術集会
    • Place of Presentation
      学術総合センター(東京)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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