| Project/Area Number |
25462520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Endo Sumio 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30646823)
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| Co-Investigator(Kenkyū-buntansha) |
Kohri Kenjiro 名古屋市立大学, 学長 (30122047)
Yasui Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
Okada Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
Niimi Kazuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (70551274)
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| Research Collaborator |
Ito Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 尿路結石 / cyclophilin D / ミトコンドリア / 酸化ストレス |
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| Outline of Final Research Achievements |
In this study by using the cyclophilin D deficient mice, we elucidate the effect of cyclophilin D to the formation of urinary tract stones in initial step at the molecular level, and aimed at the development of a prophylactic agent of urinary tract stones by inactivation of cyclophilin D.
When the oxidative stress such as oxalic acid stimulation applies to renal tubular cells, cyclophilin D is active and mitochondria collapse. This promotes oxidative stress and formation of urinary tract stone, we elucidat. So we prove inactivation of cyclophilin D suppress urinary stone formation. We think that it is a study that leads to the development of preventive medicine of the urinary stone.
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