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Investigation for the role of GDNF in benign prostate hyperplasia

Research Project

Project/Area Number 25462522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

Takada Masa  名古屋市立大学, 医学(系)研究科(研究院), 研究員 (60468254)

Co-Investigator(Kenkyū-buntansha) KUBOTA Yasue  名古屋市立大学, 大学院医学研究科, 講師 (00381830)
IMURA Makoto  名古屋市立大学, 大学院医学研究科, 研究員 (00551269)
SHIBATA Yasuhiro  名古屋市立大学, 大学院医学研究科, 助教 (10534745)
KOHRI Kenjiro  名古屋市立大学, 学長 (30122047)
SASAKI Shoichi  名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
KOJIMA Yoshiyuki  福島県立医科大学, 医学部, 教授 (60305539)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords前立腺肥大症 / 泌尿器科学 / GDNF / 間質増生 / 前立腺
Outline of Final Research Achievements

Benign prostate hyperplasia is a non-cancerous enlargement of the prostate which cause lower urinary tract symptoms, such as urinary frequency, urinary urgency interrupted urine stream and so on. Aging society increase the BPH prevalence and these symptoms degrade the quality of life. Although BPH is common, the cause of BPH is still unclear.
To investigate the mechanism of BPH development, we use the novel BPH model which was made by implanting the urogenital sinus of neonatal rats to sub-capsule of the prostate of adult male rats.  Using this model we discovered the grail-cell derived neurotrophic factor (GDNF) plays the important role in interstitial cell proliferation.
In this study, we demonstrate the GDNF increase the growth rate of human prostate interstitial cell line, and in these cell line signal cascade such as RET phosphorylation pathway and GZF1 were activated.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice.2015

    • Author(s)
      Watanabe M, Ueda T, Shibata Y, Kumamoto N, Ugawa S.
    • Journal Title

      Neuroreport

      Volume: 26 Issue: 3 Pages: 173-178

    • DOI

      10.1097/wnr.0000000000000322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuroendocrine carcinoma of the kidney and bladder with loss of heterozygosity and changes in chromosome 3 copy number.2015

    • Author(s)
      23.Okada Atsushi, Iida Keitaro, Hamakawa Takashi, Umemoto Yukihiro, Yasui Takahiro, Kawai Noriyasu, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      American Journal of Case Report

      Volume: 16 Pages: 611-616

    • DOI

      10.12659/ajcr.894274

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス前庭系有毛細胞におけるASIC1bの発現と分布2016

    • Author(s)
      柴田 泰宏、星川 真理子、熊本 奈都子、植田 高史、鵜川 眞也
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 複雑性女子尿道憩室術後に腹圧性失禁を生じた1例2016

    • Author(s)
      濱川 隆、佐々木 昌一、野崎 哲史、高田 麻沙、窪田 泰江、安井 孝周
    • Organizer
      第21回東海排尿障害研究会
    • Place of Presentation
      名鉄ニューグランドホテル(愛知県名古屋市)
    • Year and Date
      2016-02-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 過活動膀胱治療における服薬状況および患者の満足度に関するアンケート調査2015

    • Author(s)
      窪田 泰江、濱川 隆、高田 麻沙、梅本 幸裕、河合 憲康、佐々木 昌一、郡 健二郎、安井 孝周
    • Organizer
      第65回日本泌尿器科学会中部総会
    • Place of Presentation
      長良川国際会議場、岐阜都ホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高度乏精子症における精子採取の検討2015

    • Author(s)
      武田 知樹、永井 隆、梅本 幸裕、岩月 正一郎、窪田 泰江、神谷 浩行、窪田 裕樹、阪野 里花、佐々木 昌一、林 祐太郎、郡 健二郎、安井 孝周
    • Organizer
      第65回日本泌尿器科学会中部総会
    • Place of Presentation
      長良川国際会議場、岐阜都ホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] ロボット支援前立腺全摘除術が及ぼす夜間頻尿への影響2015

    • Author(s)
      濱川 隆、佐々木 昌一、高田 麻沙、窪田 泰江、河合 憲康、戸澤 啓一、郡 健二郎、安井 孝周
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      京王プラザホテル札幌(北海道札幌市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 前立腺肥大症の発生誘引物質としてのGDNFの可能性2013

    • Author(s)
      柴田泰宏 佐々木昌一 濱川隆 高田麻沙 井村誠 水野健太郎 岡田淳志 梅本幸裕 安井孝周 河合憲康 窪田泰江 林祐太郎 郡健二郎
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館 (札幌市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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