| Project/Area Number |
25462524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Tozawa Keiichi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40264733)
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| Co-Investigator(Kenkyū-buntansha) |
KOHRI Kenjiro 名古屋市立大学, 学長 (30122047)
HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
HIROSE Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員 (60381894)
OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / 酸化ストレス / NF-kB / クルクミン / 結石形成阻害 / オステオポンチン |
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| Outline of Final Research Achievements |
Kidney stone formation has been recognized as a metabolic syndrome (MetS)-related disease. The aims of the present study were to elucidate a possible mechanism of kidney stone formation under MetS conditions by using MetS mouse model and to assess the effectiveness of curcumin treatment for the prevention of kidney stone. Wild-type (+/+) and ob/ob mice (having a disorder in which to produce leptin) were administered daily doses of 50 mg/kg glyoxylate (GOx) for 6 days. To prevent kidney stone formation, exogenous curcumin treatment (2%) was administered daily. At day 3, 7 and 14, their kidneys were extracted.
Curcumin inhibited NF-kB activation, oxidative stress and CaOX deposition in renal tubular cells. this study showed that curcumin treatment prevented kidney stone formation by inhibition of NF-kB activation, inflammation and apoptosis.
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