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Prevention of urolithiasis using anti-NF-kB drugs

Research Project

Project/Area Number 25462524
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

Tozawa Keiichi  名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40264733)

Co-Investigator(Kenkyū-buntansha) KOHRI Kenjiro  名古屋市立大学, 学長 (30122047)
HAYASHI Yutaro  名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
HIROSE Yasuhiko  名古屋市立大学, 大学院医学研究科, 研究員 (60381894)
OKADA Atsushi  名古屋市立大学, 大学院医学研究科, 講師 (70444966)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords尿路結石 / メタボリックシンドローム / 酸化ストレス / NF-kB / クルクミン / 結石形成阻害 / オステオポンチン
Outline of Final Research Achievements

Kidney stone formation has been recognized as a metabolic syndrome (MetS)-related disease. The aims of the present study were to elucidate a possible mechanism of kidney stone formation under MetS conditions by using MetS mouse model and to assess the effectiveness of curcumin treatment for the prevention of kidney stone. Wild-type (+/+) and ob/ob mice (having a disorder in which to produce leptin) were administered daily doses of 50 mg/kg glyoxylate (GOx) for 6 days. To prevent kidney stone formation, exogenous curcumin treatment (2%) was administered daily. At day 3, 7 and 14, their kidneys were extracted.
Curcumin inhibited NF-kB activation, oxidative stress and CaOX deposition in renal tubular cells. this study showed that curcumin treatment prevented kidney stone formation by inhibition of NF-kB activation, inflammation and apoptosis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Proinflammatory and Metabolic Changes Facilitate Renal Crystal Deposition in an Obese Mouse Model of Metabolic Syndrome.2015

    • Author(s)
      Taguchi K, Okada A, Hamamoto S, Iwatsuki S, Naiki T, Ando R, Mizuno K, Tozawa K, Kohri K, Yasui T.
    • Journal Title

      J Urol.

      Volume: 194 Issue: 6 Pages: 1787-96

    • DOI

      10.1016/j.juro.2015.07.083

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 尿路結石に用いる薬2015

    • Author(s)
      戸澤啓一、岡田淳志、安井孝周
    • Journal Title

      泌尿器ケア

      Volume: 20 Pages: 54-59

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 尿路結石症2015

    • Author(s)
      田口和己、戸澤啓一、安井孝周
    • Journal Title

      臨床泌尿器科

      Volume: 69 Pages: 163-166

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis2013

    • Author(s)
      Fujii Y, Okada A, Yasui T, Niimi K,Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e61343-e61343

    • DOI

      10.1371/journal.pone.0061343

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between the incidence of urolithiasis and nutrition based on Japanese National Health and Nutrition Surveys.2013

    • Author(s)
      Yasui T, Okada A, Hamamoto S, Hirose M, Ando R, Kubota Y, Tozawa K, Hayashi Y, Gao B, Suzuki S, Kohri K
    • Journal Title

      Urolithiasis

      Volume: 41 Pages: 217-24

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 肥満における腎結石形成では腎の動脈硬化関連因子の発現が亢進する2015

    • Author(s)
      藤井 泰普、太田 裕也、池上 要介、永田 大介、丸山 哲史、岡田 淳志、田口 和己、濵本 周造、安藤 亮介、矢内 良昌、坂倉 毅、戸澤 啓一、郡 健二郎、安井 孝周
    • Organizer
      第65回日本泌尿器科学会中部総会
    • Place of Presentation
      長良川国際会議場、岐阜都ホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 尿路結石分子標的治療を目指した網羅的遺伝子解析によるRandall’s Plaqueの発症制御遺伝子の同定2015

    • Author(s)
      田口 和己、浜本 周造、海野 怜、宇佐美 雅之、伊藤 靖彦、広瀬 真仁、安藤 亮介、岡田 淳志、藤田 圭治、戸澤 啓一、安井 孝周、郡 健二郎
    • Organizer
      日本尿路結石症学会第25回学術集会
    • Place of Presentation
      ロワジールホテル旭川(北海道旭川市)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] マルチプレックス解析を用いたシュウ酸カルシウム患者に特異的な尿中マクロファージ関連因子の同定2015

    • Author(s)
      岡田 淳志、海野 怜、田口 和己、遠藤 純央、小林 隆宏、廣瀬 泰彦、藤井 泰普、宇佐美 雅之、浜本 周造、安藤 亮介、矢内 良昌、伊藤 恭典、戸澤 啓一、安井 孝周、郡 健二郎
    • Organizer
      日本尿路結石症学会第25回学術集会
    • Place of Presentation
      ロワジールホテル旭川(北海道旭川市)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] メタボリックシンドロームにおける腎結石形成では、腎の動脈硬化関連因子の発現が亢進する2014

    • Author(s)
      藤井 泰普、岡田 淳志、田口 和己、廣瀬 泰彦、濵本 周造、安藤 亮介、梅本 幸裕、安井 孝周、戸澤 啓一、郡 健二郎
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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