Prevention of urolithiasis using anti-NF-kB drugs
| Project/Area Number |
25462524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Tozawa Keiichi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40264733)
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| Co-Investigator(Kenkyū-buntansha) |
KOHRI Kenjiro 名古屋市立大学, 学長 (30122047)
HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
HIROSE Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員 (60381894)
OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / 酸化ストレス / NF-kB / クルクミン / 結石形成阻害 / オステオポンチン |
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| Outline of Final Research Achievements |
Kidney stone formation has been recognized as a metabolic syndrome (MetS)-related disease. The aims of the present study were to elucidate a possible mechanism of kidney stone formation under MetS conditions by using MetS mouse model and to assess the effectiveness of curcumin treatment for the prevention of kidney stone. Wild-type (+/+) and ob/ob mice (having a disorder in which to produce leptin) were administered daily doses of 50 mg/kg glyoxylate (GOx) for 6 days. To prevent kidney stone formation, exogenous curcumin treatment (2%) was administered daily. At day 3, 7 and 14, their kidneys were extracted.
Curcumin inhibited NF-kB activation, oxidative stress and CaOX deposition in renal tubular cells. this study showed that curcumin treatment prevented kidney stone formation by inhibition of NF-kB activation, inflammation and apoptosis.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] The association between the incidence of urolithiasis and nutrition based on Japanese National Health and Nutrition Surveys.2013
Author(s)
Yasui T, Okada A, Hamamoto S, Hirose M, Ando R, Kubota Y, Tozawa K, Hayashi Y, Gao B, Suzuki S, Kohri K
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Journal Title
Urolithiasis
Volume: 41
Pages: 217-24
Related Report
Peer Reviewed
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