Role of protein Z that is one of urinary stone matrix proteins in the progress of arteriosclerosis
Project/Area Number |
25462528
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
YAMAOKA Noriko 帝京大学, 薬学部, 准教授 (90582859)
FUKUUCHI Tomoko 帝京大学, 薬学部, 助教 (10389116)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | プロテインZ / 尿路結石症 / マトリックスタンパク質 / シュウ酸カルシウム結晶 / 尿路結石 / プロテインZ / COM結晶の凝集 / COM結晶の成長 / 結晶の凝集 |
Outline of Final Research Achievements |
A thrombus and arteriosclerosis are the severe clinical condition of the life. We analyzed urinary stones in detail, and confirmed that protein Z which suppresses blood clotting was included in a high frequency in the urinary stone and examined its role in the formation of urinary calculus. As a result, protein Z was detected in urinary stones that was composed of calcium oxalate monohydrate and it was found that protein Z made crystal of calcium oxalate monohydrate increase on the lipid membrane. Protein Z is expected to suppress blood clotting, but it is considered that protein Z has different role on generation of urinary calculus.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Targeting uric acid and the inhibition of progression to end-stage renal disease -A propensity score analysis.2015
Author(s)
Uchida S, Chang WX, Ota T, Tamura Y, Shiraishi T, Kumagai T, Shibata S, Fujigaki Y, Hosoyamada M, Kaneko K, Shen ZY, Fujimori S.
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Journal Title
PLoS One
Volume: 10
Issue: 12
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 豆類に含まれるプリン体量の測定2016
Author(s)
樋口華捺、高柳ふくえ、神代くるみ、福内 友子, 山岡 法子, 安田 誠, 馬渡 健一,中込 和哉, 金子希代子
Organizer
日本薬学会 第136年会
Place of Presentation
横浜市(神奈川)
Year and Date
2016-03-27
Related Report
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[Presentation] LC-MSを用いた高プリン体食負荷におけるマウス血しょう、尿および臓器中のプリン・ピリミジン塩基の体内動態の評価2016
Author(s)
河野 眞土加, 早川 洸, 秋元 南, 東 奈実, 酒井 紫帆, 富岡 直子, 福内 友子,山岡 法子, 安田 誠, 馬渡 健一, 中込 和哉, 細山田 真, 金子 希代子
Organizer
日本薬学会 第136年会
Place of Presentation
横浜市(神奈川)
Year and Date
2016-03-27
Related Report
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