Primary aldosteronism: Assessment of tissue-sparing adrenalectomy according to the results of segmental adrenal venous sampling
Project/Area Number |
25462532
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Tohoku University |
Principal Investigator |
ISHIDOYA SHIGETO 東北大学, 医学(系)研究科(研究院), 非常勤講師 (00344656)
|
Co-Investigator(Kenkyū-buntansha) |
KAWASAKI YOSHIHIDE 東北大学, 医学系研究科, 助教 (80722256)
TAKASE KEI 東北大学, 医学系研究科, 教授 (60361094)
KAIHO YASUHIRO 東北大学, 医学系研究科, 講師 (30447130)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 原発性アルドステロン症 / 腹腔鏡手術 / 副腎静脈サンプリング / 部分切除術 |
Outline of Final Research Achievements |
We investigated whether tissue-sparing laparoscopic bilateral adrenal surgery was applicable or not for patients with bilateral primary aldosteronism (PA). Endocrinological examination was conducted for patients with hypertension and PA patients were selected. Segmental adrenal venous sampling (sAVS) was performed for PA patients. Then bilateral intara-adrenal venous map has become apparent which enabled us to recognize the aldosterone-hypersecreting regions. Urologists performed laparoscopic bilateral adrenal surgery with partial conservation (LBASpc) for selected 42 patients with bilateral PA disease. All patients were normalized plasma aldosterone concentration (PAC) and 98 % achieved reduction of antihypertensive medication after LBASpc. Moreover, 72% of patients has become free from corticoid replacement therapy (CRT) after surgery. Preoperative PAC was the risk factor for persistent CRT. The study indicated that LBASpc could be applicable for selected patients with bilateral PA.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery.2016
Author(s)
R Morimoto, N Satani, Y Iwakura, Y Ono, M Kudo, M Nezu, K Omata, Y Tezuka, K Seiji, H Ota, Y Kawasaki, S Ishidoya, Y Nakamura, Y Arai, K Takase, H Sasano, S Ito, F Satoh
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Journal Title
Journal of human hypertension
Volume: 30
Issue: 6
Pages: 379-385
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization.2016
Author(s)
N Satani, H Ota, K Seiji, R Morimoto, M Kudo, Y Iwakura, Y Ono, M Nezu, K Omata, S Ito, F Satoh, K Takase
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Journal Title
Radiology
Volume: 278(1)
Issue: 1
Pages: 265-274
DOI
Related Report
Peer Reviewed
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[Journal Article] Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling.2016
Author(s)
H Ota, K Seiji, M Kawabata, N Satani, K Omata, Y Ono, Y Iwakura, R Morimoto, Ti Matsuura, M Kudo, J Tominaga, F Satoh, S Ito, K Takase
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Journal Title
European radiology
Volume: 26(3)
Issue: 3
Pages: 622-630
DOI
Related Report
Peer Reviewed
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[Journal Article] PROGRESS IN PRIMARY ALDOSTERONISM:Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism?2015
Author(s)
Satoh F, Morimoto R, Seiji K, Satani N, Ota H, Iwakura Y, Ono Y, Kud, M, Nezu M, Omata K, Tezuka Y, Kawasaki Y, Ishidoya S, Arai Y, Takase K, Nakamura Y, McNamara K, Sasano H, Ito S.
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Journal Title
Eur J Endocrinol.
Volume: 173(4)
Issue: 4
Pages: 465-477
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Measurement of Peripheral Plasma 18-Oxo-cortisol Can Discriminate Uni-lateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism2015
Author(s)
F. Satoh, R. Morimoto, Y. Ono, Y. Iwakura, K Omata, M. Kudo, K. Takase, K. Seiji, H. Sasamoto, S. Honma, M. Okuyama, K. Yamashita, CE.Gomez-Sanchez, WE. Rainey, Y. Arai, H. Sasano, Y. Nakamura, S. Ito
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Journal Title
Hypertension
Volume: 65
Issue: 5
Pages: 1096-1102
DOI
Related Report
Peer Reviewed / Open Access
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