A new therapy for blood purification of oxidative stress and uremic toxin verified by mouse kidney transplantation

• Project/Area Number: 25462533
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tohoku University
• Principal Investigator: Abe Michiaki 東北大学, 大学病院, 准教授 (40400246)
• Co-Investigator(Kenkyū-buntansha): 清元 秀泰 東北大学, 学内共同利用施設等, 教授 (00304585) ; 佐藤 恵美子 東北大学, 薬学研究科(研究院), 助教 (20466543) ; 城 謙輔 東北大学, 医学(系)研究科(研究院), 教授 (10057086)
• Research Collaborator: OKUDA HIROSHI 東北メディカル・メガバンク機構, 大学院生
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 血液浄化 / 尿毒症性物質 / 腎移植実験 / 慢性腎臓病 / マウス腎移植実験 / 尿毒症物質 / 腎臓病 / 酸化ストレス / 国際研究者交流、USA

Outline of Final Research Achievements

The project including a mouse kidney transplantation was extremely so difficult to accomplish in Japan that our graduate student studied abroad and carry forward the experiment in Duke University Medical Center, kidney research institute (Prof. Coffman TM) one and a half years ago. The donor mouse kidney, the size as same as adzuki bean, is quickly transplanted to a recipient mouse under an ophthalmologic microscope in 11-0 suture without injuring the renal artery, vein and ureter. This project has been going still now.
The final aim of this project is development of a new therapeutic agent for chronic kidney disease by blood purification of uremic material and oxidation stress. As the new candidate drug was found, I started a cohort study of it.

Research Products

• [Int'l Joint Research] Duke University School of Medicine/Kidney Research Core Centers/Thomas M. Coffman(米国)
• [Journal Article] Standard method for ultrasound evaluation of renal arterial lesions. (2016)
  • Author(s): Matsuo H, Abe M, Iwashima Y, Odashiro K, Sato H, Takase K, Hirai T, Matsumura M, Miki T.
  • Journal Title: Journal of Medical Ultrasonics Volume: 43 Issue: 1 Pages: 145-162
  • DOI: 10.1007/s10396-015-0651-3
  • Peer Reviewed / Open Access
• [Journal Article] Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals (2015)
  • Author(s): Nagasaki M, Yasuda J, Katsuoka F, Nariai N, Kojima K, Kawai Y, Yamaguchi-Kabata Y, Yokozawa J, Danjoh I, Saito S, Sato Y, Mimori T, Tsuda K, Saito R, Pan X, Nishikawa S, Ito S, Kuroki Y, Tanabe O, Fuse N, Kuriyama S, Kiyomoto H, Hozawa A, Minegishi N, Engel J D, Kinoshita K, Kure S, Yaegashi N, Yamamoto M.
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 8018-8018
  • DOI: 10.1038/ncomms9018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prominent hyperplasia of renin-producing juxtaglomerular apparatus after chronic and complete blockade of the renin-angiotensin system in adult IgA nephropathy (2015)
  • Author(s): Abe M, Joh K, Ieiri N, Hotta O, Utsunomiya Y, Sato H, Kisu K, Sakumo N, Kiyomoto H, Sato T, Taguma Y, Ito S
  • Journal Title: CEN Case Rep Volume: 4 Issue: 2 Pages: 228-232
  • DOI: 10.1007/s13730-015-0177-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. (2015)
  • Author(s): Cowley AW Jr, Abe M, Mori T, O'Connor PM, Ohsaki Y, Zheleznova NN
  • Journal Title: Am J Physiol Renal Physiol Volume: 308 Issue: 3 Pages: F179-F197
  • DOI: 10.1152/ajprenal.00455.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pro Pro内科：腎臓 片側腎動脈狭窄症患者におけるPTRAと薬物療法の選択 (2015)
  • Author(s): 阿部 倫明
  • Journal Title: 日本医事新報 Volume: 4652 Pages: 53-55
• [Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis (2013)
  • Author(s): Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
  • Journal Title: J Am Soc Nephrol Volume: 24 Issue: 10 Pages: 1599-1616
  • DOI: 10.1681/asn.2013010030
  • Peer Reviewed / Open Access
• [Journal Article] A rare case among hypertensive patients: how do we handle reninomas? (2013)
  • Author(s): Okuda H, Abe M, Kiyomoto H.
  • Journal Title: Intern Med. Volume: 52 Pages: 1853-1853
  • NAID: 130003365800
  • Peer Reviewed
• [Presentation] “心血管と腎の超音波診断 腎動脈エコー検査の標準化にむけて” (2013)
  • Author(s): 阿部 倫明
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Invited
• [Book] 『3.11から学んだ医療現場の脆弱生と想定外対応能力』；東日本大震災を分析する２ 震災と人間・まち・記録，初版，［編纂］平川 新・今村 文彦 (2013)
  • Author(s): 阿部倫明，清元秀泰
  • Publisher: 明石書店
• [Funded Workshop] ASN Kidney Week 2015 (2015)
  • Place of Presentation: San Diego
  • Year and Date: 2015-11-03