A new therapy for blood purification of oxidative stress and uremic toxin verified by mouse kidney transplantation
Project/Area Number |
25462533
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Tohoku University |
Principal Investigator |
Abe Michiaki 東北大学, 大学病院, 准教授 (40400246)
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Co-Investigator(Kenkyū-buntansha) |
清元 秀泰 東北大学, 学内共同利用施設等, 教授 (00304585)
佐藤 恵美子 東北大学, 薬学研究科(研究院), 助教 (20466543)
城 謙輔 東北大学, 医学(系)研究科(研究院), 教授 (10057086)
|
Research Collaborator |
OKUDA HIROSHI 東北メディカル・メガバンク機構, 大学院生
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 血液浄化 / 尿毒症性物質 / 腎移植実験 / 慢性腎臓病 / マウス腎移植実験 / 尿毒症物質 / 腎臓病 / 酸化ストレス / 国際研究者交流、USA |
Outline of Final Research Achievements |
The project including a mouse kidney transplantation was extremely so difficult to accomplish in Japan that our graduate student studied abroad and carry forward the experiment in Duke University Medical Center, kidney research institute (Prof. Coffman TM) one and a half years ago. The donor mouse kidney, the size as same as adzuki bean, is quickly transplanted to a recipient mouse under an ophthalmologic microscope in 11-0 suture without injuring the renal artery, vein and ureter. This project has been going still now. The final aim of this project is development of a new therapeutic agent for chronic kidney disease by blood purification of uremic material and oxidation stress. As the new candidate drug was found, I started a cohort study of it.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals2015
Author(s)
Nagasaki M, Yasuda J, Katsuoka F, Nariai N, Kojima K, Kawai Y, Yamaguchi-Kabata Y, Yokozawa J, Danjoh I, Saito S, Sato Y, Mimori T, Tsuda K, Saito R, Pan X, Nishikawa S, Ito S, Kuroki Y, Tanabe O, Fuse N, Kuriyama S, Kiyomoto H, Hozawa A, Minegishi N, Engel J D, Kinoshita K, Kure S, Yaegashi N, Yamamoto M.
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 8018-8018
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prominent hyperplasia of renin-producing juxtaglomerular apparatus after chronic and complete blockade of the renin-angiotensin system in adult IgA nephropathy2015
Author(s)
Abe M, Joh K, Ieiri N, Hotta O, Utsunomiya Y, Sato H, Kisu K, Sakumo N, Kiyomoto H, Sato T, Taguma Y, Ito S
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Journal Title
CEN Case Rep
Volume: 4
Issue: 2
Pages: 228-232
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis2013
Author(s)
Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
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Journal Title
J Am Soc Nephrol
Volume: 24
Issue: 10
Pages: 1599-1616
DOI
Related Report
Peer Reviewed / Open Access
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