Suppression of antibody-mediated rejction by immunoglobulin G resulting from Fc sialylation

Research Project

Project/Area Number	25462536
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Urology
Research Institution	Tokyo Women's Medical University (2015) Osaka University (2013)
Principal Investigator	Okumi Masayoshi 東京女子医科大学, 医学部, 講師 (60512978)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	腎移植 / 抗体関連型拒絶反応 / 免疫グロブリン
Outline of Final Research Achievements	2g/kg Intravenous immunoglobulin (IVIg) treatment significantly suppressed inflammation and C4d deposition in kidney allografts in a rat antibody-mediated rejection kidney transplant model. This mechanism acts, not only to reduce expression of mRNA levels of C1q and C3 in kidney allografts, but to suppress production of donor specific antibody.