| Project/Area Number |
25462537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJISAWA Masato 神戸大学, 医学研究科, 教授 (30243314)
山口 耕平 神戸大学, 医学(系)研究科(研究院), 助教 (50457107)
江夏 徳寿 神戸大学, 医学部附属病院, 助教 (30622550)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Urocortin / testicular damage / spermatogenesis / Micro-TESE / urocortin / sphingosine-1 / micro-TESE / 精子回収予測因子 |
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| Outline of Final Research Achievements |
The useful factor which can predict the existence of the testicular sperm in the case of microdissection testicular sperm extraction (Micro-TESE) has not been established, so we focused on Urocortin as a new molecular biological marker. In this study, we showed that the expression levels of Urocortin changed in response to exogeneous stress. In additon, we showed a negative correlation between the urocortin expression and the proportion of germ cells undergoing apoptosis. It has been said that the close control of germ cells by apotosis is necessary for normal spermatogenesis; so, from this perspective, it was suggested that Urocortin could be a factor which can predict the existence of the testicular sperm.
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