BK viral infection in Japanese kidney transplant patients

• Project/Area Number: 25462540
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kyushu University
• Principal Investigator: Masutani Kosuke 九州大学, 大学病院, 助教 (30419593)
• Co-Investigator(Kenkyū-buntansha): KITADA HIDEHISA 九州大学, 大学病院, 助教 (10403958) ; TSURUYA KAZUHIKO 九州大学, 医学研究院, 准教授 (20372740) ; 中野 敏昭 九州大学, 大学病院, 助教 (10432931)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: BKウイルス / 腎移植 / 免疫抑制療法 / スクリーニング / ウイルス感染症 / ポリオーマウイルス / BKウイルス腎症 / 定量的核酸同定検査 / 先行的治療 / 移植腎機能障害 / 間質線維化 / 尿細管間質性腎炎

Outline of Final Research Achievements

Polyomavirus BK nephropathy (BKVN) is an important complication in kidney transplant (KT) patients. Graft survival is extremely lower in the patient with BKVN. Those data were published from US and European countries and there is almost no data in Japanese KT patients. Thus we planned to investigate the incidence and severity of BK viral infection in Japanese patients via prospective, regular screening with polymerase chain reaction for BK viral DNA. A total of 62 living-donor KT patients received regular screening in urine and plasma. We found 14 patients who developed BK viruria, but no patient developed viremia or nephropathy. BK viruria was spontaneously disappeared in 8 patients, and 6 patients showed sustained viruria with low BK viral load. Those finding suggested that Japanese KT patients show low incidence of BK viral reactivation and the reactivation is mild under current immunosuppressive regimens.

Research Products

• [Journal Article] The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy. (2016)
  • Author(s): Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Nagata M, Tsuchimoto A, Hirakata H, Kitazono T, Tsuruya K.
  • Journal Title: Clinical and Experimental Nephrology Volume: in press
  • Peer Reviewed
• [Journal Article] Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. (2016)
  • Author(s): Eriguchi M, Yotsueda R, Torisu K, Kawai Y, Hasegawa S, Tanaka S, Noguchi H, Masutani K, Kitazono T, Tsuruya K.
  • Journal Title: American Journal of Physiology, Renal Physiology Volume: 310 (4) Issue: 4 Pages: F322-F333
  • DOI: 10.1152/ajprenal.00260.2015
  • Peer Reviewed
• [Journal Article] Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial. (2016)
  • Author(s): Masutani K, Tsuchimoto A, Yamada T, Hirakawa M, Mitsuiki K, Katafuchi R, Hirakata H, Kitazono T, Tsuruya K and West Japan Study Group for Therapy of IgA Nephropathy Investigators.
  • Journal Title: Clinical and Experimental Nephrology Volume: in press
  • Peer Reviewed
• [Journal Article] Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin. (2016)
  • Author(s): Tsuruya K, Yoshida H, Suehiro T, Fujisaki K, Masutani K, Kitazono T.
  • Journal Title: Renal Failure Volume: 38 (3) Issue: 3 Pages: 390-396
  • DOI: 10.3109/0886022x.2015.1136874
  • Peer Reviewed
• [Journal Article] Extended swan-neck catheter with upper abdominal exit-site reduces peritoneal dialysis-related infections. (2016)
  • Author(s): Eriguchi M, Tsuruya K, Yoshida H, Haruyama N, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Masutani K, Kitazono T.
  • Journal Title: Therapeutic Apheresis and Dialysis Volume: 20 (2) Issue: 2 Pages: 158-164
  • DOI: 10.1111/1744-9987.12358
  • Peer Reviewed
• [Journal Article] 腎移植患者の生活習慣病対策 (2016)
  • Author(s): 升谷耕介
  • Journal Title: 腎と透析別冊腎不全外科2016 Volume: 30 Suppl Pages: 38-41
• [Journal Article] 再発腎炎の診断・評価・留意点． (2016)
  • Author(s): 26.土本晃裕、升谷耕介、鶴屋和彦
  • Journal Title: 今日の移植 Volume: 29 Pages: 101-107
• [Journal Article] Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation during the first two months in resolving Polyomavirus BK nephropathy. (2015)
  • Author(s): Masutani K, Tsuchimoto A, Matsukuma Y, Kurihara K, Nishiki T, Kitada H, Tanaka M, Kitazono T, Tsuruya K.
  • Journal Title: Nephrology Volume: 20 Suppl 2 Issue: S2 Pages: 45-50
  • DOI: 10.1111/nep.12462
  • Peer Reviewed
• [Journal Article] Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy. (2015)
  • Author(s): Tanaka S, Ninomiya T, Masutani K, Tsuchimoto A, Tsuruya K, Kitazono T.
  • Journal Title: Clinical and Experimental Nephrology Volume: 19 (6) Pages: 1062-1070
  • Peer Reviewed
• [Journal Article] BKウイルス腎症における免疫再構築症候群 (2015)
  • Author(s): 升谷耕介
  • Journal Title: 日本臨床腎移植学会雑誌 Volume: 3 (1) Pages: 160-165
  • NAID: 40020688818
• [Journal Article] ウイルス感染と腎移植 (2015)
  • Author(s): 升谷耕介
  • Journal Title: 腎臓内科・泌尿器科 Volume: 3 (2) Pages: 118-128
• [Journal Article] Protocol biopsy findings in living donor kidney transplant patients treated with once-daily or twice-daily tacrolimus formulation. (2014)
  • Author(s): Masutani K, Tsuchimoto A, Haruyama N, Kitada H, Okabe Y, Noguchi H, Tanaka M, Tsuruya K, Kitazono T.
  • Journal Title: Transplantation Proceedings Volume: 46 Issue: 2 Pages: 395-399
  • DOI: 10.1016/j.transproceed.2013.10.050
  • Peer Reviewed
• [Journal Article] Early disappearance of urinary decoy cells in successfully treated polyomavirus BK nephropathy. (2014)
  • Author(s): Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Kitada H, Noguchi H, Tanaka M, Tsuruya K, Kitazono T.
  • Journal Title: Transplantation Proceedings Volume: 46 Issue: 2 Pages: 560-563
  • DOI: 10.1016/j.transproceed.2013.11.112
  • Peer Reviewed
• [Journal Article] HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia. (2013)
  • Author(s): Masutani K, Ninomiya T, Randhawa P
  • Journal Title: Nephrology Dialysis Transplantation Volume: 28 Issue: 12 Pages: 3119-3126
  • DOI: 10.1093/ndt/gft298
  • Peer Reviewed
• [Journal Article] Impact of flow cytometry crossmatch B-cell positivity on living renal transplantation. (2013)
  • Author(s): Kurihara K, Kitada H, Miura Y, Terasaka S, Kaku K, Miyamoto K, Tsuchimoto A, Masutani K, Tanaka M.
  • Journal Title: Transplantation Proceedings Volume: 45 Issue: 8 Pages: 2093-2096
  • DOI: 10.1016/j.transproceed.2013.08.047
  • Peer Reviewed
• [Journal Article] Renal interstitial fibrosis in 0-hour biopsy as a predictor of post-transplant anemia. (2013)
  • Author(s): Tsuchimoto A, Masutani K, Haruyama N, Nagata M, Noguchi H, Okabe Y, Kitada H, Tanaka M, Tsuruya K, Kitazono T.
  • Journal Title: American Journal of Nephrology Volume: 38 Issue: 4 Pages: 267-274
  • DOI: 10.1159/000354647
  • Peer Reviewed
• [Journal Article] 腎移植後ウイルス感染症 (2013)
  • Author(s): 升谷耕介
  • Journal Title: 日本腎臓学会誌 Volume: 55 Pages: 133-143
• [Journal Article] BKウイルス腎症の病理. (2013)
  • Author(s): 升谷耕介、Parmjeet Randhawa.
  • Journal Title: 日本臨床腎移植学会雑誌 Volume: 1 Pages: 24-29
  • NAID: 40020440224
  • Peer Reviewed
• [Journal Article] 腎移植患者におけるBKウイルス尿症単独例の臨床像. (2013)
  • Author(s): 升谷耕介、Parmjeet Randhawa.
  • Journal Title: 日本臨床腎移植学会雑誌 Volume: 1 Pages: 143-150
  • NAID: 40020445052
  • Peer Reviewed
• [Presentation] 短期プロトコール生検の意義について（0h～1年以内） (2016)
  • Author(s): 升谷耕介
  • Organizer: 第49回日本臨床腎移植学会
  • Place of Presentation: 米子市
  • Year and Date: 2016-03-23
• [Presentation] Incidence of hepatitis B viral reactivation after kidney transplantation with rituximab administration. (2015)
  • Author(s): Masutani K, Omoto K, Okumi M, Okabe Y, Kitada H, Shimizu T, Ishida H, Tanabe K, Tsuruya K, Kitazono T, and the Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.
  • Organizer: American Society of Nephrology, Kidney Week 2015
  • Place of Presentation: San Diego CA, United States
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] 移植後感染症とグラフト機能 (2015)
  • Author(s): 升谷耕介
  • Organizer: 第45回日本腎臓学会西部学術大会
  • Place of Presentation: 金沢市
  • Year and Date: 2015-10-23
• [Presentation] Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation in resolving Polyomavirus BK nephropathy (2015)
  • Author(s): Masutani K, Tsuchimoto A, Matsukuma Y, Kurihara K, Nishiki T, Kitada H, Tanaka M, Tsuruya K, Kitazono T
  • Organizer: 2015 Banff-CST Joint Scientific Meeting
  • Place of Presentation: Vancouver, BC, Canada
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] 腎移植における抗体関連拒絶（AMR）の病理と診断 up-to-date (2015)
  • Author(s): 升谷耕介
  • Organizer: 第51回日本移植学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2015-10-01
• [Presentation] 九州大学病院における先行的腎移植の現状 (2015)
  • Author(s): 升谷耕介
  • Organizer: 第60回日本透析医学会学術集会・総会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-06-26
• [Presentation] 腎移植患者の長期生着、生存のために腎臓内科医ができること (2015)
  • Author(s): 升谷耕介
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-06-05
• [Presentation] IgA腎症を対象としたミゾリビンの腎炎進行抑制効果に関するランダム化並行群間比較試験 (2015)
  • Author(s): 升谷耕介、土本晃裕、山田知美、平川亮、満生浩司、片渕律子、平方秀樹、鶴屋和彦、北園孝成
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-06-05
• [Presentation] Histological analysis in ABO-compatible and incompatible kidney transplantation by performing 3-month and 1-year protocol biopsies. (2015)
  • Author(s): Masutani K, Tsuchimoto A, Matsukuma Y, Kurihara K, Okabe Y, Kitada H, Tanaka M, Tsuruya K, Kitazono T
  • Organizer: American Transplant Congress 2015
  • Place of Presentation: Philadelphia, PA, United States
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Beneficial effect of once-daily prolonged-release tacrolimus on kidney allograft fibrosis at one-year post-transplantation. (2013)
  • Author(s): Masutani K, Tsuchimoto A, Kitada H, Okabe Y, Noguchi H, Tsuruya K, Tanaka M, Kitazono T.
  • Organizer: The 13th Congress of the Asian Society for Transplantation
  • Place of Presentation: Kyoto, Japan
• [Presentation] Early disappearance of urinary decoy cells in successfully treated polyomavirus BK nephropathy. (2013)
  • Author(s): Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Kitada H, Noguchi H, Tsuruya K, Tanaka M, Kitazono T.
  • Organizer: The 13th Congress of the Asian Society for Transplantation
  • Place of Presentation: Kyoto, Japan
• [Presentation] HLA-A2, HLA-B44, HLA-DR15 associate with lower risk of BK viremia while BK viruria is HLA independent. (2013)
  • Author(s): Masutani K, Randhawa P.
  • Organizer: American Society of Nephrology, Kidney Week 2013
  • Place of Presentation: Atlanta, GA, United States