| Project/Area Number |
25462540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITADA HIDEHISA 九州大学, 大学病院, 助教 (10403958)
TSURUYA KAZUHIKO 九州大学, 医学研究院, 准教授 (20372740)
中野 敏昭 九州大学, 大学病院, 助教 (10432931)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | BKウイルス / 腎移植 / 免疫抑制療法 / スクリーニング / ウイルス感染症 / ポリオーマウイルス / BKウイルス腎症 / 定量的核酸同定検査 / 先行的治療 / 移植腎機能障害 / 間質線維化 / 尿細管間質性腎炎 |
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| Outline of Final Research Achievements |
Polyomavirus BK nephropathy (BKVN) is an important complication in kidney transplant (KT) patients. Graft survival is extremely lower in the patient with BKVN. Those data were published from US and European countries and there is almost no data in Japanese KT patients. Thus we planned to investigate the incidence and severity of BK viral infection in Japanese patients via prospective, regular screening with polymerase chain reaction for BK viral DNA. A total of 62 living-donor KT patients received regular screening in urine and plasma. We found 14 patients who developed BK viruria, but no patient developed viremia or nephropathy. BK viruria was spontaneously disappeared in 8 patients, and 6 patients showed sustained viruria with low BK viral load. Those finding suggested that Japanese KT patients show low incidence of BK viral reactivation and the reactivation is mild under current immunosuppressive regimens.
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