the development of revitalization methods on kidney grafting from cardiac death donors

• Project/Area Number: 25462543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kitasato University
• Principal Investigator: IWAI SATOMI 北里大学, 獣医学部, 講師 (30566542)
• Co-Investigator(Kenkyū-buntansha): 大園 誠一郎 浜松医科大学, 医学部, 教授 (00183228) ; 小林 英司 自治医科大学, 医学部, 研究員 (00245044) ; 寺谷 工 自治医科大学, 医学部, 講師 (70373404) ; 高山 達也 自治医科大学, 医学部, 准教授 (90324350)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腎移植 / マージナル腎 / 常温保存 / 間葉系幹細胞 / 腎臓移植 / マージナルドナー / LacZ-Luc Transgenic rat / ラット腎移植モデル / バイオイメージングシステム / ラットマージナル腎移植モデル

Outline of Final Research Achievements

Normothermic preservation with an extracellular-type solution was　beneficial for the short-term storage of a marginal kidney(Iwai S. et al. PLoS One. 2012;7(3):e33157.). This approach will be able to extend the preservation period of marginal kidneys or to provide improved function of marginal kidneys for longer periods. Mesenchymal stem cells (MSC) treatment was improved compared with that in the MSC nontreatment group. Local injection of MSC is a potentially safer route of administration than is high-dosage, intravenous injection(Iwai S. et al. Transplantation proceedings, 2014;46:1578-84.).

Research Products

• [Journal Article] Impact of ex vivo administration of mesenchymal stem cells on the function of kidney grafts from cardiac death donors in rat. (2013)
  • Author(s): 10. Iwai, S., Sakonju, I., Okano, S., Teratani, T., Kasahara, N., Yokote, S., Yokoo, T. and Kobayashi, E.
  • Journal Title: Transplantation Proceedings Volume: 46 Pages: 1578-1584
  • Peer Reviewed