• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Abnormal fetal heart rate pattern and fetomaternal hemorrhage

Research Project

Project/Area Number 25462546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHokkaido University

Principal Investigator

Minakami Hisanori  北海道大学, 医学(系)研究科(研究院), 特任教授 (40102256)

Co-Investigator(Kenkyū-buntansha) Morikawa Mamoru  北海道大学, 大学院医学研究科, 講師 (00374380)
Yamada Takahiro  北海道大学, 大学院医学研究科, 特任講師 (20419948)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsαフェトプロティン / fetomaternal hemorrhage / 前置胎盤 / 常位胎盤早期剥離 / 妊娠高血圧腎症 / cerebral palsy / hemoglobin F / cardiotocogram
Outline of Final Research Achievements

Women with preeclampsia, placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) were suggested to have placental permeability dysfunction. This study aimed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications. 41 antenatal and 39 postnatal blood samples were obtained from 46 women consisting of 11 with placental permeability dysfunction (5, 3, 2, and 1 with preeclampsia, PP, PA, and PMD, respectively) and 35 controls without such complications. FMH was identified in five women, including one each with preeclampsia, PA, PP, PMD, and nocomplications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs. 2.9% [1/35]). The risk of fetal RBC trafficking into the maternal circulation may be increased in women complicated with preeclampsia, PA, PP, and PMD.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2014 2013

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability2016

    • Author(s)
      T Umazume, T Yamada, M Morikawa, S Ishikawa, T Kojima, K Cho, N Masauzi, H Minakami
    • Journal Title

      The Journal of Obstetrics and Gynaecology Research

      Volume: 未定 Issue: 6 Pages: 632-639

    • DOI

      10.1111/jog.12959

    • NAID

      120006219889

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Seasonal variation in the prevalence of pregnancy-induced hypertension in Japanese women.2014

    • Author(s)
      Morikawa M, Yamada T, Yamada T, Cho K, Sato S, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 4 Pages: 926-31

    • DOI

      10.1111/jog.12304

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet counts.2014

    • Author(s)
      Minakami H, Morikawa M, Yamada T, Yamada T, Akaishi R, Nishida R.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 3 Pages: 641-9

    • DOI

      10.1111/jog.12282

    • NAID

      120005572419

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Do uterotonic drugs increase risk of abruptio placentae and eclampsia?2014

    • Author(s)
      Morikawa M, Cho K, Yamada T, Yamada T, Sato S, Minakami H.
    • Journal Title

      Arch Gynecol Obstet

      Volume: 289 Issue: 5 Pages: 987-91

    • DOI

      10.1007/s00404-013-3101-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immune status among Japanese during nationwide rubella outbreak in Japan 2012-2013.2014

    • Author(s)
      Yamada T, Kubo T, Mochizuki J, Hashimoto E, Ohkuchi A, Ito M, Hanaoka M, Nakai A, Saito S, Unno N, Matsubara S, Minakami H.
    • Journal Title

      J Infect

      Volume: 68 Issue: 3 Pages: 300-2

    • DOI

      10.1016/j.jinf.2013.11.008

    • NAID

      120005427755

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Essential thrombocythemia as a risk factor for stillbirth.2014

    • Author(s)
      Umazume T, Yamada T, Akaishi R, Araki N, Nishida R, Morikawa M, Minakami H.
    • Journal Title

      Thromb Res

      Volume: 133 Issue: 2 Pages: 158-61

    • DOI

      10.1016/j.thromres.2013.11.004

    • NAID

      120005372347

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective risk of abruptio placentae.2014

    • Author(s)
      Morikawa M, Yamada T, Cho K, Yamada T, Sato S, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Issue: 2 Pages: 369-74

    • DOI

      10.1111/jog.12175

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes.2014

    • Author(s)
      Abe K, Hamada H, Yamada T, Obata-Yasuoka M, Minakami H, Yoshikawa H.
    • Journal Title

      Seizure

      Volume: 23 Issue: 2 Pages: 112-6

    • DOI

      10.1016/j.seizure.2013.10.003

    • NAID

      120007130535

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electronic fetal heart rate monitoring in five fetuses with Ebstein's anomaly.2014

    • Author(s)
      Morikawa M, Endo D, Yamada T, Cho K, Yamada T, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Issue: 2 Pages: 424-8

    • DOI

      10.1111/jog.12190

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Problems in methods for the detection of significant proteinuria in pregnancy.2014

    • Author(s)
      Yamada T, Kojima T, Akaishi R, Ishikawa S, Takeda M, Kawaguchi S, Nishida R, Morikawa M, Yamada T, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Issue: 1 Pages: 161-6

    • DOI

      10.1111/jog.12148

    • NAID

      120005537457

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Causes of a nationwide rubella outbreak in Japan, 2012-2013.2014

    • Author(s)
      Minakami H, Kubo T, Unno N.
    • Journal Title

      J Infect

      Volume: 68 Issue: 1 Pages: 99-101

    • DOI

      10.1016/j.jinf.2013.09.002

    • NAID

      120005427754

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Viable delivery after conservative management of a cesarean scar pregnancy.2013

    • Author(s)
      Nishida R, Yamada T, Yamada T, Morikawa M, Kawaguchi S, Minakami H.
    • Journal Title

      J Ultrasound Med.

      Volume: 32 Issue: 9 Pages: 1682-4

    • DOI

      10.7863/ultra.32.9.1682

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Number of women requiring care at a tertiary hospital equipped with a neonatal intensive care unit at night in an area with a population of 2 million.2013

    • Author(s)
      Yamada T, Cho K, Morikawa M, Yamada T, Akaishi R, Ishikawa S, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 39 Issue: 12 Pages: 1592-5

    • DOI

      10.1111/jog.12113

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radioactive cesium (134Cs and 137Cs ) content in human placenta after the Fukushima nuclear power plant accident.2013

    • Author(s)
      Suzuki M, Terada H, Unno N, Yamaguchi I, Kunugita N, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 39 Issue: 9 Pages: 1406-10

    • DOI

      10.1111/jog.12071

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unusual clinical course of preeclampsia heralded by generalized edema.2013

    • Author(s)
      Kojima T, Yamada T, Yamada T, Morikawa M, Cho K, Minakami H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 39 Issue: 11 Pages: 1538-40

    • DOI

      10.1111/jog.12080

    • NAID

      120005537458

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coagulation/fibrinolysis and laboratory characteristics of pregnant pomen with severely depressed antithrombin activity.2013

    • Author(s)
      Yamada T, Ishikawa S, Kataoka S, Uda T, Iinuma Y, Hattori R, Yamada T, Morikawa M, Kaneuchi M, Minakami H.
    • Journal Title

      Hypertens Preg

      Volume: 32 Issue: 3 Pages: 235-44

    • DOI

      10.3109/10641955.2013.792346

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi