|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|Outline of Final Research Achievements
Women with preeclampsia, placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) were suggested to have placental permeability dysfunction. This study aimed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications. 41 antenatal and 39 postnatal blood samples were obtained from 46 women consisting of 11 with placental permeability dysfunction (5, 3, 2, and 1 with preeclampsia, PP, PA, and PMD, respectively) and 35 controls without such complications. FMH was identified in five women, including one each with preeclampsia, PA, PP, PMD, and nocomplications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs. 2.9% [1/35]). The risk of fetal RBC trafficking into the maternal circulation may be increased in women complicated with preeclampsia, PA, PP, and PMD.