Analysis of human azoospermia and POF and its clinical advance
| Project/Area Number |
25462547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SENGOKU Kazuo 旭川医科大学, 医学部, 教授 (30163124)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | azoospermia / SCOS / meiosis / mutation / SNP / MA / PLK4 |
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| Outline of Final Research Achievements |
PLK-4 is a key regulator of centriole duplication and male mice with a point mutation in Plk4 are known to show azoospermia associated with germ cell loss. We found a heterozygous 13-bp deletion of PLK4 in an azoospermic patient with Sertoli cell-only syndrome (SCOS). In vitro centriole amplification was observed in wild-type PLK4-transfected cells, but not in mutant ones, indicating that the PLK4 mutation can cause azoospermia by SCOS.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile--updated 2013.2013
Author(s)
Kishi R, , Goudarzi H, Azumi K, Kanazawa A, Otake Y, Yila TA, Ait Bamai Y, Cong S, Baba T, Braimoh TS, Ban S, Washino N, Konishi K, Kato S, Uno A, Limpar M, Minakami H, Nonomura K, Mitsui T, Endo T, Baba T, Sengoku K, Saijo Y, Yoshioka E, Miyamoto T et al
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Journal Title
Environ Health Prev Med.
Volume: 18
Pages: 429-50
Related Report
Peer Reviewed
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[Journal Article] Pathogenic mutations in two families with congenital cataract identified with whole-exome sequencing.2013
Author(s)
Kondo Y, Saitsu H,Miyamoto T, Lee BJ, Nishiyama K, Nakashima M, Tsurusaki Y, Doi H, Miyake N, Kim JH, Yu YS, Matsumoto N
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Journal Title
Mol Vis.
Volume: 19
Pages: 384-389
Related Report
Peer Reviewed
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