Development of treatment strategy for age-related decline in oocyte quality by analyzing lipid metabolism

• Project/Area Number: 25462550
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Yamagata University
• Principal Investigator: Takahashi Toshifumi 山形大学, 医学部, 講師 (20302292)
• Co-Investigator(Kenkyū-buntansha): TSUTSUMI Seiji 山形大学, 医学部, 講師 (50323168) ; IGARASHI Hideki 山形大学, 医学部, 助教 (80333970) ; HARA Shuichiro 山形大学, 医学部, 助教 (10436230)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 卵の加齢 / リピドミクス / ミトコンドリア / ベータ酸化 / 脂肪酸 / 不妊症 / カルニチン / ピルビン酸脱水素酵素

Outline of Final Research Achievements

The age-associated decline in female fertility is largely attributable to the decrease in oocyte quality due to ovarian aging. However, the precise mechanisms of oocyte aging due to ovarian aging remain unknown. In the present study, we examined the molecular mechanisms of age-related decline in oocyte quality by analyzing lipid metabolism.