| Project/Area Number |
25462551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Kubota Toshiro 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50126223)
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| Co-Investigator(Kenkyū-buntansha) |
Oshima Noriko 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30611058)
Morita Ikuo 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60100129)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 子宮内炎症 / 間葉系幹細胞 / 切迫早産 / 脳室周囲白質軟化症 / 気管支肺異形成 / 早産 / 抗炎症 |
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| Outline of Final Research Achievements |
We conducted this research to develop novel therapy for preterm labor and neonatal brain and lung complication associated with intra-amniotic inflammation.
We isolated mesenchymeal stem cells from umbilical cords and placentae that could be collected by non-invasive procedure without ethical problem. We also adjusted the isolation method to get high quality cells. Umbilical cords derived mesenchymeal stem cells and chorionic villi derived mesenchymeal stem cells were used in this study because they were considered to suitable cells in clinical use. In the other hand, we established novel animal model of preterm labor and neonatal complications associated with intra-amniotic inflammation. Then assessed therapeutic efficacy of mesenchymal stem cells in these conditions. We demonstrated that mesenchymal stem cells could ameliorate local inflammation in the preterm labor model.
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