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Novel therapy for preterm lobar using mesenchymal stem cells

Research Project

Project/Area Number 25462551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kubota Toshiro  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50126223)

Co-Investigator(Kenkyū-buntansha) Oshima Noriko  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30611058)
Morita Ikuo  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60100129)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords子宮内炎症 / 間葉系幹細胞 / 切迫早産 / 脳室周囲白質軟化症 / 気管支肺異形成 / 早産 / 抗炎症
Outline of Final Research Achievements

We conducted this research to develop novel therapy for preterm labor and neonatal brain and lung complication associated with intra-amniotic inflammation.
We isolated mesenchymeal stem cells from umbilical cords and placentae that could be collected by non-invasive procedure without ethical problem. We also adjusted the isolation method to get high quality cells. Umbilical cords derived mesenchymeal stem cells and chorionic villi derived mesenchymeal stem cells were used in this study because they were considered to suitable cells in clinical use. In the other hand, we established novel animal model of preterm labor and neonatal complications associated with intra-amniotic inflammation. Then assessed therapeutic efficacy of mesenchymal stem cells in these conditions. We demonstrated that mesenchymal stem cells could ameliorate local inflammation in the preterm labor model.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Mesenchymal stem cells ameliorate intra-amniotic inflammation-related neonatal complications in rats.2015

    • Author(s)
      Honda I, Taki A, Morioka C, Komaki M, Miyasaka N, Oshima N , Morio T, Kubota T, Morita I.
    • Journal Title

      Inflammation and Regeneration

      Volume: 35(5), Pages: 261-268

    • NAID

      130005114585

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] マウス早産モデルに対する間葉系幹細胞培養上清の治療効果の検討2016

    • Author(s)
      本多泉、森丘千夏子、滝敦子、宮坂尚幸、森田育男
    • Organizer
      第52回日本周産期・新生児医学会学術集会
    • Place of Presentation
      富山国際会議場他(富山県・富山市)
    • Year and Date
      2016-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] :臍帯由来間葉系幹細胞を用いた脳室周囲白質軟化症の治療効果とその機序の解明.2015

    • Author(s)
      森丘千夏子、本多泉、滝敦子、森尾友宏、森田育男
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県・福岡市)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 子宮内炎症環境が臍帯由来間葉系幹細胞に及ぼす影響の検討.2015

    • Author(s)
      本多泉、大島乃里子、宮坂尚幸、久保田俊郎、森田育男
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Assessment of placental and neonatal complication in rat model of intra-uterine inflammation induced by intra-amniotic injection of lipopolysaccharide2014

    • Author(s)
      Izumi Honda , Chikako Morioka , Atsuko Taki , Noriko Oshima-Sudo , Motohiro Komaki , Toshiro Kubota ,Ikuo Morita
    • Organizer
      The 18th international vascular biology meeting
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Tissue engineered lymphatic microvessels using cell-printing technology2014

    • Author(s)
      Noriko Oshima Sudo , Izumi Honda , Ken-ichi Nakahama , Toshiro Kubota , Ikuo Morita
    • Organizer
      The 18th international vascular biology meeting
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳質周囲白質軟化症の新規治療法開発に向けた新生仔ラットモデルの作成と解析2014

    • Author(s)
      本多泉、須藤乃里子、久保田俊郎、森田育男
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Optimized method for culturing endothelial colony forming cells from human umbilical cord blood and tissue engineered capillary vessels using printing technology.2013

    • Author(s)
      Oshima-Sudo N , Honda I, Obayashi S, Terauchi M, Nakahama K, Kubota T, Morita I
    • Organizer
      5th Scientific Meeting of the Asia Pacific Menopause Federation
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] リンパ管再生に向けた基礎的検討2013

    • Author(s)
      須藤乃里子、本多泉、久保田俊郎、森田育男
    • Organizer
      第 21 回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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