Comprehensive gene expression analysis of neonatal ischemic-hypoxic encephalopathy animal model at acute phase

• Project/Area Number: 25462553
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Kojima Toshio 豊橋技術科学大学, 健康支援センター, 教授 (00311340)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 低酸素性虚血性脳症 / 網羅的遺伝子発現解析 / 疾患動物モデル / 新生児低酸素性虚血性脳症

Outline of Final Research Achievements

In this study, we performed comprehensive gene expression analysis of the contra-lesional cerebrum of neonatal ischemic-hypoxic encephalopathy animal model at acute phase. The results suggest that 1 hour after lesioning, inflammatory responses are induced, and that induced inflammatory reactions continue at 24 hour after lesioning. Furthermore, neuropathy progression is suggested at both 1 hour and 24 hour after lesioning. From these results, we concluded that the contra-lesional hemisphere of neonatal ischemic-hypoxic encephalopathy animal model is important subject of investigation.