Measurement of maternal cerebral tissue hemoglobin on near-infrared time-resolved spectroscopy
Project/Area Number |
25462554
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
SUZUKI KAZUNAO 浜松医科大学, 医学部附属病院, 講師 (50456571)
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Co-Investigator(Kenkyū-buntansha) |
金山 尚裕 浜松医科大学, 医学部, 理事 (70204550)
伊東 宏晃 浜松医科大学, 医学部附属病院, 教授 (70263085)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 母体脳酸素飽和度 / 近赤外線分光法 / 妊娠高血圧症候群 / 脳血液量 / 産科出血 / 酸素動態 / 分娩 / 帝王切開 |
Outline of Final Research Achievements |
To measure cerebral tissue hemoglobin in uncomplicated and complicated pregnant women during the peripartum period.Time-resolved spectroscopy (TRS-20) can measure absolute concentration of oxygenated, deoxygenated, and total tissue hemoglobin based on the transit time of individual photons. Therefore, we used TRS-20 to measure tissue hemoglobin in the hemi-prefrontal lobes of normotensive pregnant women. Cyclic labor concomitant with intra-abdominal pressure caused synergistic elevation in cerebral tissue hemoglobin. In contrast, epidural anesthesia reduced the amplitude of the cyclic increase of cerebral tissue hemoglobin in normotensive pregnant women. Hypertension in labor due to pre-eclampsia increased the amplitude of synergistic elevation of cerebral tissue hemoglobin caused by cyclic labor and intra-abdominal pressure.TRS-20 can detect specific changes in maternal cerebral tissue hemoglobin level in response to physiological and pathophysiological changes in delivery.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero.2013
Author(s)
Kohmura YK, Kanayama N, Muramatsu K, Tamura N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Aoe S, Sasaki T, Suganami T, Ogawa Y, Itoh H.
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Journal Title
Reprod Sci.
Volume: 20(7)
Pages: 813-827
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[Presentation] 近赤外線を用いた新しい分娩時の母体出血モニタリング2016
Author(s)
鈴木 一有, 向 亜紀, 川合 健太, 小田 智昭, 向 麻利, 加藤 慧子, 幸村 友季子, 内田 季之, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第52回日本周産期・新生児医学会総会学術講演会
Place of Presentation
富山市
Year and Date
2016-07-16
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[Presentation] 母体脳の酸素飽和度を直接評価する新しい分娩時母体出血モニタリング法2016
Author(s)
鈴木 一有, 向 亜紀, 深田 せり乃, 有澤 奈良, 向 麻利, 山崎 香織, 幸村 友季子, 古田 直美, 内田 季之, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第68回日本産科婦人科学会総会学術講演会
Place of Presentation
東京都
Year and Date
2016-04-21
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[Presentation] 近赤外線分光法による母体脳酸素飽和度測定 特に母体呼気二酸化炭素濃度との関連2015
Author(s)
鈴木 一有, 東堂 祐介, 鈴木 崇公, 上田 めぐみ, 向 麻利, 幸村 友季子, 古田 直美, 谷口 千津子, 内田 季之, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
日本産科婦人科学会 第67回学術講演会
Place of Presentation
横浜市
Year and Date
2015-04-09
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[Book] 産科と婦人科2013
Author(s)
鈴木一有、伊東宏晃、金山尚裕
Total Pages
5
Publisher
診断と治療社
Related Report