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To establish a model of placental dysplasia using nanomaterials

Research Project

Project/Area Number 25462555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

Mimura Kazuya  大阪大学, 医学(系)研究科(研究院), 助教 (50437422)

Co-Investigator(Kenkyū-buntansha) KANAGAWA TAKESHI  大阪大学, 医学系研究科, 招へい准教授 (40346218)
遠藤 誠之  大阪大学, 医学(系)研究科(研究院), 講師 (30644794)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords胎盤形成 / ナノマテリアル / 酸化ストレス / 妊娠高血圧症候群
Outline of Final Research Achievements

We focused on pathogenesis in placental formation, studying the effect on pregnancy-induced hypertension (PIH) and fetal growth restriction (FGR) and preterm birth. We examined oxidative stress by nanomaterials, and the effects on migration and invasion as an in vitro study. As an in vivo study, we created a hypoplastic placental model by administering nanomaterials into pregnant mice, and examined the onset of PIH and FGR. In addition, as preterm birth model progesterone and nanomaterial hydroxide Fullerene suppressed the inflammatory reaction caused by ureaplasma TLR2 dependent system. We expected effective treatment for preterm birth in mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2015 2013

All Journal Article (14 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Pregnancy management for a patient with graft occlusion after right iliac artery bypass surgery2015

    • Author(s)
      Nakae, R. Matsuzaki, S. Egawa-Takata, T. Mimura, K. Kanagawa, T. Kimura, T.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 41 Issue: 6 Pages: 979-984

    • DOI

      10.1111/jog.12636

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis2015

    • Author(s)
      Nishikawa, A. Mimura, K. Kanagawa, T. Maeda, T. Tomimatsu, T. Kimura, T.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 41 Issue: 8 Pages: 1273-1277

    • DOI

      10.1111/jog.12713

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Case Report and Literature Review of Midtrimester Termination of Pregnancy Complicated by Placenta Previa and Placenta Accreta.2015

    • Author(s)
      Matsuzaki S, Matsuzaki S, Ueda Y, Tanaka Y, Kakuda M, Kanagawa T, Kimura T.
    • Journal Title

      American Journal of Perinatology Reports

      Volume: 5 Issue: 01 Pages: e006-e011

    • DOI

      10.1055/s-0034-1395992

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraoperative red cell salvage during obstetric surgery in 50 Japanese women2015

    • Author(s)
      Morikawa, M. Kuramoto, A. Nakayama, M. Oguchi, H. Hasegawa, M. Funakoshi, T. Furukawa, S. Hirayama, E. Kanagawa, T. Kaji, T. Kasai, M. Konishi, Y. Yamamoto, S. Itakura, A. Maeda, M. Kobayashi, T. Minakami, H.
    • Journal Title

      International Journal of Gynecology & Obstetrics

      Volume: 128 Issue: 3 Pages: 256-259

    • DOI

      10.1016/j.ijgo.2014.09.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide demonstration project of next-generation sequencing of cell-free DNA in maternal plasma in Japan: 1-year experience.2015

    • Author(s)
      Sago H, Sekizawa A, Japan NIPT Consortium(Yamada T, Endo T, Hukushima A, Murotsuki J, Kamei Y et al)
    • Journal Title

      Prenat Diagn.

      Volume: 35 Issue: 4 Pages: 331-6

    • DOI

      10.1002/pd.4539

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor2015

    • Author(s)
      Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
    • Journal Title

      Reproductive Sciences

      Volume: 10 Issue: 10 Pages: 1272-80

    • DOI

      10.1177/1933719115574340

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain.2013

    • Author(s)
      Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T.
    • Journal Title

      Brain Res

      Volume: 1501 Pages: 89-97

    • DOI

      10.1016/j.brainres.2013.01.036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age2013

    • Author(s)
      Tomimatsu T, Fujime M, Kanayama T, Mimura K, Koyama S, Kanagawa T, Kimura T.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 印刷中 Issue: 1 Pages: 24-27

    • DOI

      10.1016/j.ejogrb.2013.01.016

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Normalisation of angiogenic imbalance after intra-uterine transfusion for mirror syndrome caused by parvovirus B192013

    • Author(s)
      Goa, S. Mimura, K. Kakigano, A. Tomimatsu, T. Kinugasa-Taniguchi, Y. Endo, M. Kanagawa, T. Kimura, T.
    • Journal Title

      Fetal Diagn Ther

      Volume: 34 Issue: 3 Pages: 176-179

    • DOI

      10.1159/000348778

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus2013

    • Author(s)
      Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
    • Journal Title

      Hypertens Res Pregnancy

      Volume: 2 Pages: 1-5

    • NAID

      130004638236

    • Related Report
      2013 Research-status Report
  • [Journal Article] Maternal carbon dioxide level during labor and its possible effect on fetal cerebral oxygenation: mini review.2013

    • Author(s)
      Tomimatsu T, Kakigano A, Mimura K, Kanayama T, Koyama S, Fujita S, Taniguchi Y, Kanagawa T, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 39 Issue: 1 Pages: 1-6

    • DOI

      10.1111/j.1447-0756.2012.01944.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice.2013

    • Author(s)
      Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I.
    • Journal Title

      J Reprod Immunol.

      Volume: 100(2) Issue: 2 Pages: 118-127

    • DOI

      10.1016/j.jri.2013.10.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short-term treatment of caffeine attenuates hypoxic ischemic brain damage in neonatal rats2013

    • Author(s)
      Otgonbaatar, J. Kanagawa, T. Minato, K. Mimura, K. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
    • Journal Title

      Medical Journal of Osaka University

      Volume: 55 Pages: 1-4

    • Related Report
      2013 Research-status Report
  • [Journal Article] Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report2013

    • Author(s)
      Kakigano, A. Mimura, K. Kanagawa, T. Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
    • Journal Title

      Placenta

      Volume: 34 Issue: 7 Pages: 628-630

    • DOI

      10.1016/j.placenta.2013.04.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 胎盤機能の評価―臍帯動脈・胎児血流からのアプローチ―2015

    • Author(s)
      金川武司
    • Organizer
      第38回日本母体胎児医学会学術集会
    • Place of Presentation
      大分県別府市
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Possible therapeutics for preeclampsia: Drug repositioning by In Vitro screening via induction of placental growth factor2015

    • Author(s)
      Mimura, K
    • Organizer
      ISSHP European Congress
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎盤の超音波診断2015

    • Author(s)
      金川武司
    • Organizer
      Japanese Society for the Advancement of Women's Imaging
    • Place of Presentation
      兵庫県淡路市
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肺リンパ管拡張症を伴った総肺静脈還流異常2015

    • Author(s)
      金川武司
    • Organizer
      第9回大阪胎児心臓病研究会
    • Place of Presentation
      大阪市北区
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院におけるNT肥厚症例の染色体異常、胎児心構築異常の後方視的検討2013

    • Author(s)
      中川 慧 松崎慎哉 味村和哉 熊澤惠一 橋本香映 谷口友基子 金川武司 木村 正 冨松拓治
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      札幌プリンスホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 当院におけるSLE合併妊娠分娩症例の検討2013

    • Author(s)
      高橋 恵 味村和哉 松崎慎哉 熊澤惠一 橋本香映 谷口友基子 金川武司 遠藤誠之 木村 正.
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      札幌プリンスホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 反応性低血糖合併妊娠の1例2013

    • Author(s)
      鶴房聖子 谷口友基子 味村和哉 松崎慎哉 熊澤惠一 橋本香映 遠藤誠之 金川武司 木村 正
    • Organizer
      第128回近畿産科婦人科学会
    • Place of Presentation
      ピアザ淡海 滋賀県立県民交流センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 多彩な合併症を伴い、治療に難渋したJarcho-Levin症候群類縁疾患の一例2013

    • Author(s)
      冬木真規子 荒堀仁美 谷口英俊 松浪桂 和田和子 味村和哉 金川武司 香川尚己 奈良啓悟 臼井規朗
    • Organizer
      第49回日本周産期・新生児医学会
    • Place of Presentation
      パシフィコ横浜・会議センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 培養細胞を用いたTLR2を介するNF-kB転写活性に対するプロゲステロン、フラーレンの抑制効果2013

    • Author(s)
      脇本 哲 味村和哉 内田 薫 金川武司 木村 正 柳原格
    • Organizer
      第49回日本周産期・新生児医学会
    • Place of Presentation
      パシフィコ横浜・会議センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 母体血清中のangiogenic imbalanceと胎盤の avascular edematous cystic villiを認めたトリソミー13合併妊娠2013

    • Author(s)
      柿ヶ野藍子 味村和哉 金川武司 中山雅弘 金山智子 藤田聡子 谷口友基子 遠藤誠之 冨松拓治 木村正
    • Organizer
      第49回日本周産期・新生児医学会
    • Place of Presentation
      パシフィコ横浜・会議センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 母体血清中のangiogenic imbalanceと胎盤の avascular edematous cystic villiを認めたトリソミー13合併妊娠2013

    • Author(s)
      柿ヶ野藍子 味村和哉 金川武司 中山雅弘 金山智子 藤田聡子 谷口友基子 遠藤誠之 冨松拓治 木村正
    • Organizer
      第21回日本胎盤学会
    • Place of Presentation
      ウインクあいち
    • Related Report
      2013 Research-status Report
  • [Book] 改訂3版 MFICUマニュアル2015

    • Author(s)
      全国周産期医療(MFICU)連絡協議会
    • Total Pages
      752
    • Publisher
      メディカ出版
    • Related Report
      2015 Annual Research Report
  • [Book] 周産期診療べからず集 [母体・胎児編]妊婦健診時の尿蛋白・尿糖の異常を軽んずるべからず2015

    • Author(s)
      金川武司
    • Total Pages
      920
    • Publisher
      東京医学者
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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