To establish a model of placental dysplasia using nanomaterials

• Project/Area Number: 25462555
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: Mimura Kazuya 大阪大学, 医学(系)研究科(研究院), 助教 (50437422)
• Co-Investigator(Kenkyū-buntansha): KANAGAWA TAKESHI 大阪大学, 医学系研究科, 招へい准教授 (40346218) ; 遠藤 誠之 大阪大学, 医学(系)研究科(研究院), 講師 (30644794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 胎盤形成 / ナノマテリアル / 酸化ストレス / 妊娠高血圧症候群

Outline of Final Research Achievements

We focused on pathogenesis in placental formation, studying the effect on pregnancy-induced hypertension (PIH) and fetal growth restriction (FGR) and preterm birth. We examined oxidative stress by nanomaterials, and the effects on migration and invasion as an in vitro study. As an in vivo study, we created a hypoplastic placental model by administering nanomaterials into pregnant mice, and examined the onset of PIH and FGR. In addition, as preterm birth model progesterone and nanomaterial hydroxide Fullerene suppressed the inflammatory reaction caused by ureaplasma TLR2 dependent system. We expected effective treatment for preterm birth in mice.

Research Products

• [Journal Article] Pregnancy management for a patient with graft occlusion after right iliac artery bypass surgery (2015)
  • Author(s): Nakae, R. Matsuzaki, S. Egawa-Takata, T. Mimura, K. Kanagawa, T. Kimura, T.
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 41 Issue: 6 Pages: 979-984
  • DOI: 10.1111/jog.12636
  • Peer Reviewed / Open Access
• [Journal Article] Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis (2015)
  • Author(s): Nishikawa, A. Mimura, K. Kanagawa, T. Maeda, T. Tomimatsu, T. Kimura, T.
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 41 Issue: 8 Pages: 1273-1277
  • DOI: 10.1111/jog.12713
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Case Report and Literature Review of Midtrimester Termination of Pregnancy Complicated by Placenta Previa and Placenta Accreta. (2015)
  • Author(s): Matsuzaki S, Matsuzaki S, Ueda Y, Tanaka Y, Kakuda M, Kanagawa T, Kimura T.
  • Journal Title: American Journal of Perinatology Reports Volume: 5 Issue: 01 Pages: e006-e011
  • DOI: 10.1055/s-0034-1395992
  • Peer Reviewed / Open Access
• [Journal Article] Intraoperative red cell salvage during obstetric surgery in 50 Japanese women (2015)
  • Author(s): Morikawa, M. Kuramoto, A. Nakayama, M. Oguchi, H. Hasegawa, M. Funakoshi, T. Furukawa, S. Hirayama, E. Kanagawa, T. Kaji, T. Kasai, M. Konishi, Y. Yamamoto, S. Itakura, A. Maeda, M. Kobayashi, T. Minakami, H.
  • Journal Title: International Journal of Gynecology & Obstetrics Volume: 128 Issue: 3 Pages: 256-259
  • DOI: 10.1016/j.ijgo.2014.09.008
  • Peer Reviewed / Open Access
• [Journal Article] Nationwide demonstration project of next-generation sequencing of cell-free DNA in maternal plasma in Japan: 1-year experience. (2015)
  • Author(s): Sago H, Sekizawa A, Japan NIPT Consortium(Yamada T, Endo T, Hukushima A, Murotsuki J, Kamei Y et al)
  • Journal Title: Prenat Diagn. Volume: 35 Issue: 4 Pages: 331-6
  • DOI: 10.1002/pd.4539
  • Peer Reviewed / Open Access
• [Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor (2015)
  • Author(s): Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
  • Journal Title: Reproductive Sciences Volume: 10 Issue: 10 Pages: 1272-80
  • DOI: 10.1177/1933719115574340
  • Peer Reviewed
• [Journal Article] Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain. (2013)
  • Author(s): Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T.
  • Journal Title: Brain Res Volume: 1501 Pages: 89-97
  • DOI: 10.1016/j.brainres.2013.01.036
  • Peer Reviewed
• [Journal Article] Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age (2013)
  • Author(s): Tomimatsu T, Fujime M, Kanayama T, Mimura K, Koyama S, Kanagawa T, Kimura T.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol Volume: 印刷中 Issue: 1 Pages: 24-27
  • DOI: 10.1016/j.ejogrb.2013.01.016
  • Peer Reviewed
• [Journal Article] Normalisation of angiogenic imbalance after intra-uterine transfusion for mirror syndrome caused by parvovirus B19 (2013)
  • Author(s): Goa, S. Mimura, K. Kakigano, A. Tomimatsu, T. Kinugasa-Taniguchi, Y. Endo, M. Kanagawa, T. Kimura, T.
  • Journal Title: Fetal Diagn Ther Volume: 34 Issue: 3 Pages: 176-179
  • DOI: 10.1159/000348778
  • Peer Reviewed
• [Journal Article] Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus (2013)
  • Author(s): Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
  • Journal Title: Hypertens Res Pregnancy Volume: 2 Pages: 1-5
  • NAID: 130004638236
• [Journal Article] Maternal carbon dioxide level during labor and its possible effect on fetal cerebral oxygenation: mini review. (2013)
  • Author(s): Tomimatsu T, Kakigano A, Mimura K, Kanayama T, Koyama S, Fujita S, Taniguchi Y, Kanagawa T, Kimura T.
  • Journal Title: J Obstet Gynaecol Res. Volume: 39 Issue: 1 Pages: 1-6
  • DOI: 10.1111/j.1447-0756.2012.01944.x
  • Peer Reviewed
• [Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice. (2013)
  • Author(s): Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I.
  • Journal Title: J Reprod Immunol. Volume: 100(2) Issue: 2 Pages: 118-127
  • DOI: 10.1016/j.jri.2013.10.001
  • Peer Reviewed
• [Journal Article] Short-term treatment of caffeine attenuates hypoxic ischemic brain damage in neonatal rats (2013)
  • Author(s): Otgonbaatar, J. Kanagawa, T. Minato, K. Mimura, K. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
  • Journal Title: Medical Journal of Osaka University Volume: 55 Pages: 1-4
• [Journal Article] Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report (2013)
  • Author(s): Kakigano, A. Mimura, K. Kanagawa, T. Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
  • Journal Title: Placenta Volume: 34 Issue: 7 Pages: 628-630
  • DOI: 10.1016/j.placenta.2013.04.001
  • Peer Reviewed
• [Presentation] 胎盤機能の評価―臍帯動脈・胎児血流からのアプローチ― (2015)
  • Author(s): 金川武司
  • Organizer: 第38回日本母体胎児医学会学術集会
  • Place of Presentation: 大分県別府市
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] Possible therapeutics for preeclampsia: Drug repositioning by In Vitro screening via induction of placental growth factor (2015)
  • Author(s): Mimura, K
  • Organizer: ISSHP European Congress
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] 胎盤の超音波診断 (2015)
  • Author(s): 金川武司
  • Organizer: Japanese Society for the Advancement of Women's Imaging
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2015-09-04
  • Invited
• [Presentation] 肺リンパ管拡張症を伴った総肺静脈還流異常 (2015)
  • Author(s): 金川武司
  • Organizer: 第９回大阪胎児心臓病研究会
  • Place of Presentation: 大阪市北区
  • Year and Date: 2015-06-07
• [Presentation] 当院におけるNT肥厚症例の染色体異常、胎児心構築異常の後方視的検討 (2013)
  • Author(s): 中川 慧 松崎慎哉 味村和哉 熊澤惠一 橋本香映 谷口友基子 金川武司 木村 正 冨松拓治
  • Organizer: 第65回日本産科婦人科学会
  • Place of Presentation: 札幌プリンスホテル
• [Presentation] 当院におけるSLE合併妊娠分娩症例の検討 (2013)
  • Author(s): 高橋 恵 味村和哉 松崎慎哉 熊澤惠一 橋本香映 谷口友基子 金川武司 遠藤誠之 木村 正.
  • Organizer: 第65回日本産科婦人科学会
  • Place of Presentation: 札幌プリンスホテル
• [Presentation] 反応性低血糖合併妊娠の1例 (2013)
  • Author(s): 鶴房聖子 谷口友基子 味村和哉 松崎慎哉 熊澤惠一 橋本香映 遠藤誠之 金川武司 木村 正
  • Organizer: 第128回近畿産科婦人科学会
  • Place of Presentation: ピアザ淡海 滋賀県立県民交流センター
• [Presentation] 多彩な合併症を伴い、治療に難渋したJarcho-Levin症候群類縁疾患の一例 (2013)
  • Author(s): 冬木真規子 荒堀仁美 谷口英俊 松浪桂 和田和子 味村和哉 金川武司 香川尚己 奈良啓悟 臼井規朗
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜・会議センター
• [Presentation] 培養細胞を用いたTLR2を介するNF-ｋB転写活性に対するプロゲステロン、フラーレンの抑制効果 (2013)
  • Author(s): 脇本 哲 味村和哉 内田 薫 金川武司 木村 正 柳原格
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜・会議センター
• [Presentation] 母体血清中のangiogenic imbalanceと胎盤の avascular edematous cystic villiを認めたトリソミー13合併妊娠 (2013)
  • Author(s): 柿ヶ野藍子 味村和哉 金川武司 中山雅弘 金山智子 藤田聡子 谷口友基子 遠藤誠之 冨松拓治 木村正
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜・会議センター
• [Presentation] 母体血清中のangiogenic imbalanceと胎盤の avascular edematous cystic villiを認めたトリソミー13合併妊娠 (2013)
  • Author(s): 柿ヶ野藍子 味村和哉 金川武司 中山雅弘 金山智子 藤田聡子 谷口友基子 遠藤誠之 冨松拓治 木村正
  • Organizer: 第21回日本胎盤学会
  • Place of Presentation: ウインクあいち
• [Book] 改訂3版 MFICUマニュアル (2015)
  • Author(s): 全国周産期医療（MFICU）連絡協議会
  • Total Pages: 752
  • Publisher: メディカ出版
• [Book] 周産期診療べからず集 [母体・胎児編]妊婦健診時の尿蛋白・尿糖の異常を軽んずるべからず (2015)
  • Author(s): 金川武司
  • Total Pages: 920
  • Publisher: 東京医学者