Fertility preservation for girls and young women with cancer: Induction of vascularization into heterotopic ovarian tissue transplantation in a xenograft model
| Project/Area Number |
25462557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA HITOMI 大阪大学, 医学(系)研究科(研究院), 助教 (80467571)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuihiko 京都大学, 再生医科学研究所, 教授 (50211371)
KIMURA Tadashi 大阪大学, 大学院医学系研究科, 教授 (90240845)
TSUTSUI Tateki 大阪大学, 大学院医学系研究科, 准教授 (00294075)
KUMASAWA Keiichi 大阪大学, 大学院医学系研究科, 助教 (90444546)
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| Research Collaborator |
TANAKA Ayaka
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生殖医学 |
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| Outline of Final Research Achievements |
To improve the quality of life of young cancer survivors, there has recently been more discussion about the fertility preservation option. Ovarian tissue preservation is one option for fertility preservation for young cancer patients, but for some of them it is the only option. Worldwide there are only about 20 babies reported as being born using cryopreserved ovarian tissues.
We hypothesized that the low efficiency of this procedure might be caused by lack of blood supply for the transplanted ovarian tissues. We tried to develop a new controlled release sheet which can induce the formation of new vessels to supply enough blood to the transplanted ovarian tissues.
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Report
(3 results)
Research Products
(70 results)
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[Journal Article] Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia.2016
Author(s)
Kumagai M, Marui A, Tabata Y, Takeda T, Yamamoto M, Yonezawa A, Tanaka S, Yanagi S, Ito-Ihara T, Ikeda T, Murayama T, Teramukai S, Katsura T, Matsubara K, Kawakami K, Yokode M, Shimizu A, Sakata R.
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Journal Title
Heart Vessel
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.2016
Author(s)
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
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Journal Title
Gynecol Obstet Invest
Volume: in press
Related Report
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[Journal Article] Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor.2015
Author(s)
Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
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Journal Title
Reprod Sci
Volume: 10
Pages: 1272-1280
DOI
Related Report
Peer Reviewed
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[Journal Article] Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction2015
Author(s)
Nakajima K, Fujita J, Matsui M, Tohyama S, Tamura N, Kanazawa H, Seki T, Kishino Y, Hirano A, Okada M, Tabei R, Sano M, Goto S, Tabata Y, Fukuda K.
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Journal Title
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Low serum concentrations of anti-Müllerian hormone are common in 53 female childhood cancer survivors2014
Author(s)
Miyoshi Y, Ohta H, Namba N, Tachibana M, Miyamura T, Miyashita E, Hashii Y, Oue T, Isobe A, Tsutsui T, Kimura T, Ozono K
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Journal Title
Horm Res Paediat
Volume: 79
Pages: 17-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Utility of risk-weighted surgical-pathological factors in early-stage cervical cancer2013
Author(s)
Matsuo, K. Mabuchi, S. Okazawa, M. Matsumoto, Y. Tsutsui, T. Fujita, M. Kamiura, S. Ogawa, K. Morrow, C. P. Kimura, T.
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Journal Title
Br J Cancer
Volume: 108
Pages: 1348-1357
DOI
Related Report
Peer Reviewed
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[Journal Article] A phase II study of a combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 Study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 Study)2013
Author(s)
Ueda, Y. Miyatake, T. Nagamatsu, M. Yamasaki, M. Nishio, Y. Yoshino, K. Fujita, M. Tsutsui, T. Enomoto, T. Kimura, T.
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Journal Title
Eur J Obstet Gyn R B
Volume: 170
Pages: 259-263
DOI
Related Report
Peer Reviewed
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[Journal Article] A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy as an adjuvant treatment for early-stage cervical cancer patients with positive pelvic lymph nodes2013
Author(s)
Mabuchi, S. Takahashi, R. Isohashi, F. Yokoi, T. Ito, K. Tsutui, T. Ogata, T. Yoshioka, Y. Ogawa, K. Kimura, T.
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Journal Title
Int J Gynecol Cancer
Volume: 23
Pages: 1279-1286
DOI
Related Report
Peer Reviewed
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[Presentation] Development of a new local drug delivery system for the uterus using bio-nanocapsule2015
Author(s)
Koizumi, K. Nakamura, H. Matsuzaki, T. Kuroda, S. Yasui, Y. Furuya, K. Miyake, T. Takiuchi, T. Kumasawa, K. Kimura, T.
Organizer
American Society for Reproductive Medicine 2015 Annual Meeting
Place of Presentation
Baltimore, U.S.A.
Year and Date
2015-10-19
Related Report
Int'l Joint Research
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