Potential role of environment in utero on obesogenic and diabetogenic trait and a novel therapeutic target
| Project/Area Number |
25462558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
Masuyama Hisashi 岡山大学, 医歯(薬)学総合研究科, 准教授 (30314678)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Yuji 岡山大学大学院医歯薬学総合研究科, 産科婦人科学, 教授 (80218817)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肥満 / 子宮内環境 / 次世代への影響 / メタボリック症候群 / アディポサイトカイン / 核内受容体 |
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| Outline of Final Research Achievements |
Obesity and insulin resistance in the mother might play a direct role in the transmission of an obesogenic and diabetogenic trait from generation to generation, but the role of genes and a shared environment are not completely understood.
We observed that a high fat diet induced obesity in pregnant mice resulted in hypertension, proteinuria, and macrosomia with insulin resistance and abnormal adipocytokine levels and that the exposure to a high fat diet in utero might lead to a metabolic syndrome-like phenomenon through epigenetic modifications of the genes encoding adipocytokines, adiponectin and leptin in the offspring. We also demonstrated that activation of constitutive androstane receptor ameliorated the glucose metabolism in both mothers and adult offspring. Epigenetic changes of adipocytokine genes might play important roles in the origin of metabolic syndrome in adulthood of offspring and constitutive androstane receptor might be a potential therapeutic target.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy 182016
Author(s)
N. Suzumori, T. Ebara, T. Yamada, O. Samura O, J. Yotsumoto, M. Nishiyama, K. Miura K, H. Sawai H, J. Murotsuki J, M. Kitagawa M, Y. Kamei Y, H. Masuzaki, F. Hirahara F, JS. Saldivar , N. Dharajiya, H. Sago, A. Sekizawa A; Japan NIPT Consortium, H. Masuyama,
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Journal Title
J Hum Genet
Volume: 印刷中
Issue: 7
Pages: 647-652
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] 糖尿病と妊娠2015
Author(s)
増山 寿
Organizer
広島県中部地区産婦人科医会学術講演会
Place of Presentation
広島
Year and Date
2015-07-01
Related Report
Invited
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