Long-term melatonin treatment for the prevention of ovarian aging.
| Project/Area Number |
25462559
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
TAMURA Hiroshi 山口大学, 医学(系)研究科(研究院), 准教授 (50379947)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASADA Hiromi 山口大学, 医学部附属病院, 講師 (90526906)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | メラトニン / 卵巣 / 卵子 / 加齢 / 活性酸素 |
|---|
| Outline of Final Research Achievements |
Ovarian aging is dominated by a gradual decreasing numbers of follicles, coinciding with diminished quality of oocytes. The present study was undertaken to examine whether long-term melatonin treatment prevents ovarian aging in mice. Female ICR mice (10 weeks old) were randomly divided into two groups: half were fed with water as a control (C) and the other half water supplemented with melatonin (M) until 43 weeks. The numbers of oocytes recovered from the oviduct were greater in the Melatonin group compared with the Control group. The fertilization rate and blastocyst rate of in vitro fertilization were higher in the M group compared with the C group. The number of primordial, primary, secondary and antral follicle in ovary were higher in the Melatonin group compared with the Control group.
Long-term melatonin treatment increased the number of ovulated oocytes and fertilization rates. The present results indicate that melatonin prevents ovarian aging in mice.
|
Report
(3 results)
Research Products
(9 results)
-
[Journal Article] Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice2015
Author(s)
Tanabe M, Tamura H, Taketani T, Okada M, Lee L, Tamura I, Maekawa R, Asada H, Yamagata Y, Sugino N.
-
Journal Title
Journal of Reproduction and Development
Volume: 61
Issue: 1
Pages: 35-41
DOI
NAID
ISSN
0916-8818, 1348-4400
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
